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Emerging Perspectives on Adverse Childhood Experiences and Brain Cancer Immunotherapy
John W Figg1, Julian Mark2, Caretia J Washington2
1Preston A. Wells Jr. Center for Brain Tumor Therapy, Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, FL 32611, USA.
Cancers
|June 26, 2026
Summary
Adverse childhood events (ACEs) may impact cancer immunotherapy effectiveness, particularly for brain cancers like glioblastoma. Understanding this link is crucial for developing targeted neuro-psycho-immunology treatments and improving patient outcomes.
Area of Science:
- Neuroscience
- Immunology
- Oncology
- Psychology
Background:
- Adverse childhood events (ACEs) are linked to long-term health issues, including increased cancer risk and altered immune function.
- Cancer immunotherapy is a growing field, but its effectiveness can be influenced by various patient factors.
- The impact of early-life adversity on the central nervous system's immune response in the context of brain cancer immunotherapy is largely unexplored.
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