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Related Concept Videos

Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
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The Tumor Microenvironment

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Mismatch Repair

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Related Experiment Video

Updated: Jun 27, 2026

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

MMPs' Impact on Carcinogenesis in Specific Organs and Systems.

Marta Lewoc-Magnuszewska1, Barbara Choromańska1, Mateusz Maciejczyk2

  • 11st Department of General and Endocrine Surgery, Medical University of Bialystok, 24a M. Sklodowskiej-Curie Street, 15-276 Bialystok, Poland.

Cancers
|June 26, 2026
PubMed
Summary

Matrix metalloproteinases (MMPs) are key in cancer progression. Targeting specific MMPs, not all, is crucial for effective cancer therapy, moving beyond their matrix-degrading roles.

Keywords:
MMPscarcinogenesismetalloproteinases

Related Experiment Videos

Last Updated: Jun 27, 2026

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Published on: December 19, 2019

Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Cancer presents significant global health and economic challenges.
  • Matrix metalloproteinases (MMPs), zinc-dependent proteases, are implicated in carcinogenesis and metastasis.
  • MMPs' roles extend beyond extracellular matrix remodeling to intra- and extracellular signaling.

Purpose of the Study:

  • To review the characteristics and functions of MMPs in various cancers.
  • To highlight MMPs' evolving roles in the tumor microenvironment.
  • To assess the therapeutic potential of MMP inhibition.

Main Methods:

  • Literature review of MMP functions in cancer.
  • Analysis of MMPs' roles in carcinogenesis and metastasis.
  • Evaluation of evidence regarding MMP inhibition strategies.

Main Results:

  • MMPs are versatile regulators of signaling pathways.
  • MMPs act as complex modulators of the tumor microenvironment.
  • Non-selective MMP inhibition shows limited therapeutic efficacy.

Conclusions:

  • Targeting specific MMPs is more promising than broad-spectrum inhibition.
  • Therapeutic strategies should consider specific MMPs and cancer stages.
  • A nuanced approach to MMPs is needed for effective cancer treatment.