Related Experiment Video
Updated: Jun 27, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
MMPs' Impact on Carcinogenesis in Specific Organs and Systems
Marta Lewoc-Magnuszewska1, Barbara Choromańska1, Mateusz Maciejczyk2
11st Department of General and Endocrine Surgery, Medical University of Bialystok, 24a M. Sklodowskiej-Curie Street, 15-276 Bialystok, Poland.
Matrix metalloproteinases (MMPs) are key in cancer progression. Targeting specific MMPs, not all, is crucial for effective cancer therapy, moving beyond their matrix-degrading roles.
Area of Science:
- Oncology
- Biochemistry
- Molecular Biology
Background:
- Cancer presents significant global health and economic challenges.
- Matrix metalloproteinases (MMPs), zinc-dependent proteases, are implicated in carcinogenesis and metastasis.
- MMPs' roles extend beyond extracellular matrix remodeling to intra- and extracellular signaling.
Purpose of the Study:
- To review the characteristics and functions of MMPs in various cancers.
- To highlight MMPs' evolving roles in the tumor microenvironment.
- To assess the therapeutic potential of MMP inhibition.
Main Methods:
- Literature review of MMP functions in cancer.
- Analysis of MMPs' roles in carcinogenesis and metastasis.
- Evaluation of evidence regarding MMP inhibition strategies.
Main Results:
- MMPs are versatile regulators of signaling pathways.
- MMPs act as complex modulators of the tumor microenvironment.
- Non-selective MMP inhibition shows limited therapeutic efficacy.
Conclusions:
- Targeting specific MMPs is more promising than broad-spectrum inhibition.
- Therapeutic strategies should consider specific MMPs and cancer stages.
- A nuanced approach to MMPs is needed for effective cancer treatment.
Related Concept Videos
Mutagenicity and Carcinogenicity
The Tumor Microenvironment
Abnormal Proliferation
Cellular Adaptation IV: Dysplasia and Metaplasia
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Role of Matrix Metalloproteases in Degradation of ECM
A...