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Updated: Jun 27, 2026
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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
Prognostic Factors and Survival Outcomes in Resectable Thoracic Soft Tissue and Bone Sarcomas
Gökce Yavuz1, Julia Walter1, Kaan Sarı1
1Division of Thoracic Surgery, University Hospital LMU Munich, 81377 Munich, Germany.
Cancers
|June 26, 2026
Summary
High tumor grade, larger size, and incomplete resection are key predictors of poor survival in thoracic sarcoma patients. Surgery may suffice for low-grade tumors, but aggressive treatment is vital for high-grade sarcomas.
Area of Science:
- Oncology
- Surgical Oncology
- Pathology
Background:
- Thoracic sarcomas are rare, diverse mesenchymal tumors.
- Identifying prognostic factors is crucial for patient management.
Purpose of the Study:
- To determine prognostic factors for overall survival (OS) and progression-free survival (PFS) in patients with primary thoracic sarcomas undergoing resection.
Main Methods:
- Retrospective review of 84 patients with primary intrathoracic or chest wall sarcomas (2005-2020).
- Univariate and multivariate Cox regression analyses were used to identify prognostic factors for PFS and OS.
Main Results:
- High tumor grade (G3) independently predicted worse PFS and OS.
- Larger tumor size and incomplete resection were associated with worse OS.
- Lung metastases at diagnosis independently predicted worse PFS.
Conclusions:
- Histological grade is the strongest predictor of survival in resected thoracic sarcoma.
- Surgery alone may be adequate for low-grade sarcomas.
- Multimodal treatment is recommended for high-grade thoracic sarcomas.
