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Longitudinal Evaluation of Sternocleidomastoid Muscle Stiffness and Self-Reported Fibrosis-Related Symptoms After
Kaat Verbeelen1,2,3,4, An De Groef1,3,4, Kaat Van Aperen2,3,5
1MOVANT Research Group, Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, 2610 Antwerp, Belgium.
Background/Objectives:
Post-radiation fibrosis is a common complication in patients with head and neck cancer (HNC), characterised by increased tissue stiffness and functional limitations. Shear wave elastography (SWE) enables objective assessment of tissue stiffness, while self-reported outcome measures provide insight into symptom burden. However, the longitudinal evolution of these outcomes and their relationship remains insufficiently described. This study aimed to characterise post-radiation fibrosis over time using objective SWE measurements of sternocleidomastoid (SCM) muscle stiffness and self-reported fibrosis-related symptoms, and to examine their longitudinal association.
Methods:
This prospective longitudinal study included 56 patients with HNC undergoing primary or postoperative (chemo)radiotherapy. Muscle stiffness was measured using SWE, and fibrosis-related symptoms were assessed with the Lymphoedema Symptom Intensity and Distress Survey-Head and Neck (LSIDS-H&N) at 1 week, 6 weeks, 12 weeks, 6 months, and 12 months after the start of radiotherapy. Longitudinal analyses were performed using mixed-effects models adjusted for surgery and radiation dose, and within-subject associations were evaluated using repeated measures correlation.
Results:
Muscle stiffness increased over time, with estimated mean stiffness values rising from 4.12 m/s at baseline to 4.76 m/s at 6 months and 4.92 m/s at 12 months. Significant increases were observed at 6 months (p = 0.007) and 12 months (p = 0.012) compared with baseline. In contrast, self-reported fibrosis-related symptoms remained stable, with no significant differences between time points. No significant within-subject association was found between muscle stiffness and self-reported fibrosis-related symptoms (r = -0.13, p = 0.498).
Conclusions:
Muscle stiffness measured with SWE increased over time following radiotherapy, whereas self-reported fibrosis-related symptoms remained stable. No significant longitudinal association was found between these outcomes, suggesting they may capture different aspects of fibrosis.
