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Related Experiment Video

Updated: Jun 27, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

Association Between Metabolic Syndrome and Prostate Cancer: A Systematic Review.

Supriya Peshin¹, Ehab Takrori², Bhavesh Mohan Lal³

¹Department of Internal Medicine, Norton Community Hospital, Ballad Health System, Norton, VA 24273, USA.

|June 26, 2026

Summary

This summary is machine-generated.

Metabolic syndrome, a cluster of conditions like obesity and insulin resistance, shows inconsistent links to overall prostate cancer risk. However, it may be associated with more aggressive disease features.

Keywords:

cardiometabolic risk insulin resistance metabolic syndrome prostate cancer

Related Experiment Videos

Last Updated: Jun 27, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

Area of Science:

Oncology
Metabolic Health
Epidemiology

Background:

Metabolic syndrome, characterized by obesity, insulin resistance, hypertension, and dyslipidemia, is a global health issue.
Emerging research suggests a link between metabolic dysregulation and prostate cancer development and progression, but findings are inconsistent.

Purpose of the Study:

To systematically review and evaluate the association between metabolic syndrome and prostate cancer risk.
To assess the relationship between metabolic syndrome and prostate cancer clinicopathologic characteristics and disease outcomes.

Main Methods:

A comprehensive systematic literature search was performed across multiple databases, including PubMed/MEDLINE, Google Scholar, and Wiley Online Library.
Twenty-four observational studies (cohort and case-control) were included after rigorous screening and eligibility assessment.
Risk of bias was evaluated using standardized tools, and findings were synthesized narratively due to study heterogeneity.

Main Results:

Evidence for a consistent association between metabolic syndrome and overall prostate cancer incidence was inconclusive.
A potential association was observed between metabolic syndrome and clinically significant, high-grade, or adverse pathological prostate cancer features.
Individual components, particularly obesity and insulin resistance, may significantly influence these associations.

Conclusions:

The relationship between metabolic syndrome and prostate cancer outcomes is heterogeneous.
While overall incidence links are inconsistent, metabolic syndrome may be associated with more aggressive prostate cancer.
Further well-designed prospective studies are necessary to clarify causal pathways and the role of individual metabolic components.