Neural Correlates of Inhibitory Control in Impulsivity Traits in Non-Ecological Human-Computer Tasks: An ALE...

Background/Objectives: Response inhibition is the capacity to restrain impulsive actions, representing a pivotal facet of cognitive control. Although several studies report a dynamic relationship between impulsivity and inhibitory control, the neural mechanisms remain unclear. The aim of the present study is to explore neural correlates of response inhibition as a function of impulsive personality traits. Methods: For this purpose, two groups of fMRI studies conducted on subjects with and without impulsive traits were compared. The selected studies were included based on both the impulsivity levels and the performance of the subjects in inhibitory human-computer tasks (e.g., Go/No-go, Stop-signal). This was done to minimize potential differences due to samples' performances. Neuroimaging data were analyzed with an Activation Likelihood Estimation (ALE) meta-analysis approach. Results: Results reveal highly congruent clusters encompassing subcortical and prefrontal brain regions in both impulsive and non-impulsive subjects, albeit with subtle distinctions. Specifically, a direct contrast highlighted different activity in the right Middle and Superior Frontal Gyrus during inhibition tasks in the impulsive group. Conclusions: These findings deepen our comprehension of the neural mechanisms governing inhibitory control in human impulsivity. Understanding such mechanisms is increasingly relevant in today's world, where frequent interactions with artificial systems may challenge or modulate inhibitory control, with potential implications for everyday behavior.