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Related Experiment Video

Updated: Jun 27, 2026

Patch Clamp Recording of Starburst Amacrine Cells in a Flat-mount Preparation of Deafferentated Mouse Retina
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Patch Clamp Recording of Starburst Amacrine Cells in a Flat-mount Preparation of Deafferentated Mouse Retina

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Synaptic Inputs to OFF Parasol Ganglion Cells in Macaque Retina: An Analysis Using Serial Blockface Scanning Electron

David W Marshak1, Andrea S Bordt2, Nicole B Harris1

  • 1Department of Neurobiology and Anatomy, McGovern Medical School, Houston, TX 77030, USA.

Brain Sciences
|June 26, 2026
PubMed
Summary

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Phase diversity improves retinal image quality in adaptive optics scanning light ophthalmoscopy.

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Phase diversity improves retinal image quality in adaptive optics scanning light ophthalmoscopy.

bioRxiv : the preprint server for biology·2025
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Amacrine cell inputs to OFF midget ganglion cells in macaque retina.

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Inner Limiting Membrane Peel Extends In Vivo Calcium Imaging of Retinal Ganglion Cell Activity Beyond the Fovea in Non-Human Primate.

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Asymmetric Activation of Retinal ON and OFF Pathways by AOSLO Raster-Scanned Visual Stimuli.

bioRxiv : the preprint server for biology·2025

Researchers identified specific amacrine cells that provide input to OFF parasol cells in the primate retina. This reveals key neural circuits and informs understanding of visual processing differences between retinal ganglion cell types.

Area of Science:

  • Neuroscience
  • Retinal circuitry
  • Visual processing

Background:

  • Retinal ganglion cells (RGCs) are crucial for visual information transmission.
  • Parasol cells are a major type of primate RGC with distinct morphology and function.
  • Amacrine cells constitute the majority of inputs to RGCs, but their specific roles are less understood.

Purpose of the Study:

  • To identify the types of amacrine cells that synapse onto the OFF parasol subtype of RGCs.
  • To elucidate the cellular composition of the inhibitory and excitatory inputs to OFF parasol cells.

Main Methods:

  • Serial block-face scanning electron microscopy (SEM) of adult macaque central retinal tissue.
  • Reconstruction of all OFF parasol cells within the analyzed retinal volume.
Keywords:
amacrine cellbipolar cellelectron microscopyinterneuronmagnocellularprimate

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Related Experiment Videos

Last Updated: Jun 27, 2026

Patch Clamp Recording of Starburst Amacrine Cells in a Flat-mount Preparation of Deafferentated Mouse Retina
08:44

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Published on: October 13, 2016

Recording Light-evoked Postsynaptic Responses in Neurons in Dark-adapted, Mouse Retinal Slice Preparations Using Patch Clamp Techniques
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Recording Light-evoked Postsynaptic Responses in Neurons in Dark-adapted, Mouse Retinal Slice Preparations Using Patch Clamp Techniques

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Simultaneous Whole-cell Recordings from Photoreceptors and Second-order Neurons in an Amphibian Retinal Slice Preparation
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Simultaneous Whole-cell Recordings from Photoreceptors and Second-order Neurons in an Amphibian Retinal Slice Preparation

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  • Detailed analysis of synaptic inputs to individual OFF parasol cells.

    • Main Results:

    • OFF parasol cells receive over 80% of their synaptic input from amacrine cells.
    • Narrow-field amacrine cells predominated among the presynaptic inputs.
    • Five specific amacrine cell types (AII, A4, knotty bistratified type 1, A13, wiry type 1) were identified as direct inputs.

    Conclusions:

    • The identified amacrine cell types are also presynaptic to OFF midget ganglion cells.
    • Differences in light responses between midget and parasol cells may stem from distinct presynaptic bipolar cell inputs.