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Psychosurgery

Psychosurgery

Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...

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Updated: Jun 27, 2026

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Published on: August 16, 2024

Hemispherotomy for Pediatric Post-Traumatic Epilepsy.

Habib E Akouri¹, Samuel B Tomlinson², Kevin Wojcik³

¹Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

|June 26, 2026

Summary

This summary is machine-generated.

Hemispherotomy effectively treated drug-resistant hemispheric post-traumatic epilepsy (PTE) in five children, significantly reducing seizures. This epilepsy surgery offers promising outcomes for pediatric traumatic brain injury survivors.

Keywords:

epilepsy hemispherotomy pediatrics post-traumatic epilepsy traumatic brain injury

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Area of Science:

Pediatric Neurosurgery
Epilepsy Surgery
Traumatic Brain Injury

Background:

Drug-resistant hemispheric epilepsy can stem from traumatic brain injury (TBI).
Hemispherotomy is established for other hemispheric epilepsies but understudied for TBI-related cases.
Post-traumatic epilepsy (PTE) affects approximately 10% of pediatric TBI survivors.

Purpose of the Study:

To evaluate the efficacy of hemispherotomy in pediatric patients with drug-resistant hemispheric PTE secondary to TBI.
To assess seizure control and functional outcomes following hemispherotomy for TBI-induced epilepsy.

Main Methods:

Retrospective review of five pediatric patients undergoing hemispherotomy for drug-resistant PTE (2018-2022).
Patients had prior craniectomy/cranioplasty following TBI.
Seizure outcomes classified using Engel criteria; functional outcomes and complications reviewed.

Main Results:

All five pediatric patients achieved Engel Class Ia seizure outcomes post-hemispherotomy.
Median anti-seizure medication use decreased from five to one post-surgery.
No re-operations were required; neuropsychological outcomes varied, with most showing mixed results.

Conclusions:

Hemispherotomy is a viable and effective treatment for drug-resistant hemispheric PTE in children following TBI.
The procedure leads to excellent seizure reduction and potentially improved neuropsychological function.
Further research into TBI as an indication for hemispherotomy is warranted.