Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

Interactions Between Signaling Pathways

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

Negative Regulator Molecules

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.

DNA Damage can Stall the Cell Cycle

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...

DNA Damage Can Stall the Cell Cycle

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Functional Diversity and Emerging Roles of Human NME/NDPK Group II Proteins.

International journal of molecular sciences·2026

Same author

Repressive regulatory function of seryl-tRNA synthetase on VEGFA gene expression is impaired in renal cell carcinoma.

Croatian medical journal·2026

Same author

Enhancing Cancer Therapy with Hyperthermia: Synergistic Effects with Natural Compounds and Conventional Treatments.

International journal of molecular sciences·2026

Same author

Special Issue "Targeting Oxidative Stress for Disease: 2nd Edition".

International journal of molecular sciences·2025

Same author

Antitumor and Antiangiogenic Effect of Tannic Acid in the Advanced Stage of Ehrlich Ascites Tumor in Mice.

International journal of molecular sciences·2025

Same author

Quercetin as a Therapeutic Option in a Rat Model of Aluminum Chloride- and D-Galactose-Induced Neurodegeneration.

International journal of molecular sciences·2025

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

The p53 Isoforms as Potential Biomarkers in Different Cancer Entities.

Christine Supina Pavić¹, Anđela Horvat¹, Ana Tadijan²

¹Laboratory for Protein Dynamics, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia.

International Journal of Molecular Sciences

|June 26, 2026

Summary

The p53 protein, a key tumor suppressor, has numerous isoforms arising from the TP53 gene. Understanding these p53 isoforms and their roles in cancer is crucial for developing new therapeutic strategies.

Keywords:

cancer p53 isoforms tumor suppressor p53

More Related Videos

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

Establishment of a Clinic-based Biorepository

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Related Experiment Videos

Last Updated: Jun 27, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

Published on: December 30, 2025

Establishment of a Clinic-based Biorepository

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

Area of Science:

Molecular Biology
Cancer Biology
Genetics

Background:

The p53 protein is a critical tumor suppressor frequently altered in human cancers.
The TP53 gene generates diverse p53 protein isoforms through alternative splicing and translation initiation.
These isoforms can modulate the function of full-length p53, impacting cancer development.

Purpose of the Study:

To review recent research on the p53 isoform network.
To explore isoform expression profiles and biological functions in common cancer types.
To discuss therapeutic strategies targeting p53 isoforms.

Main Methods:

Literature review of novel research on p53 isoforms.
Analysis of isoform expression patterns in various cancers.
Discussion of direct and indirect targeting mechanisms for p53 isoforms.

Main Results:

p53 isoform expression varies significantly across different tumor types and normal tissues.
Isoform-specific functions influence tumorigenesis pathways like apoptosis, cell cycle, and stemness.
Differential expression impacts cancer progression and patient outcomes.

Conclusions:

Understanding the p53 isoform network is essential for cancer biology.
Targeting specific p53 isoforms offers potential for novel cancer therapies.
Further research into p53 regulation could enhance existing cancer treatments.