Association of E-Selectin with Inflammation, Mineral and Bone Disorder, and Endothelial Dysfunction in Hemodialysis...

Endothelial dysfunction is an early step in atherogenesis, and adhesion molecules such as E-selectin may serve as biomarkers or therapeutic targets. This study aimed to evaluate the relationship between E-selectin and inflammatory, nutritional, and mineral-bone metabolism markers in hemodialysis (HD) patients, as well as its association with endothelial function assessed by flow-mediated dilation (FMD). We conducted a cross-sectional study including 68 HD patients (mean age 59.7 ± 12.5 years). Clinical and laboratory parameters were assessed, including inflammatory, nutritional, and mineral-bone disorder markers. Associations with E-selectin were analyzed using bivariate and multivariable models. Endothelial function was evaluated using FMD. In multivariable analysis, alkaline phosphatase (ALP) (p = 0.002), intact parathyroid hormone (iPTH) (p = 0.001), white blood cell count (WBC) (p = 0.015), and soluble CD163 (sCD163) (p = 0.042) were independently associated with E-selectin. In the subgroup with high hs-CRP values, a significant increase was observed in both E-selectin levels and adiposity tissue markers (adipose tissue mass and waist circumference). In younger patients with inflammation, E-selectin was inversely correlated with FMD (ρ = -0.64, p = 0.008). In conclusion, E-selectin was associated with markers of inflammation, mineral-bone disorder, and endothelial dysfunction in hemodialysis (HD) patients. Novel associations of E-Selectin with sCD163 and ALP were identified.