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Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
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Innovative Facial Contouring Using a Monopolar Radiofrequency Device with Continuous Water Cooling: An Integrated

Hyojin Roh1,2, Young In Lee1,3, Jinyoung Jung2

  • 1Department of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

International Journal of Molecular Sciences
|June 26, 2026
PubMed
Summary

A novel monopolar radiofrequency with continuous water cooling (RF-CWC) system improved facial contour and skin quality. This advanced RF-CWC technology offers effective, safe, and patient-friendly facial rejuvenation with enhanced extracellular matrix remodeling.

Keywords:
RF-CWCagingcontinuous water coolingextracellular matrixmonopolar radiofrequencyrejuvenation

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Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Biomedical Engineering

Background:

  • Monopolar radiofrequency (MRF) is used for facial rejuvenation but limited by discomfort and inconsistent heating.
  • Optimizing thermal delivery and patient comfort are key for improving MRF efficacy.

Purpose of the Study:

  • To evaluate the efficacy, safety, and mechanisms of a novel MRF system with continuous water cooling (RF-CWC).
  • To assess the system's impact on facial aesthetics and skin extracellular matrix (ECM) components.

Main Methods:

  • A prospective clinical trial with 22 female participants using the RF-CWC system.
  • Ex vivo human skin and in vivo porcine models were used to analyze cellular and molecular responses.
  • Histological, immunohistochemical, and ELISA analyses assessed ECM components and inflammatory markers.

Main Results:

  • Statistically significant improvements in jawline lifting, midface volume, and lower face contour were observed (p < 0.001).
  • RF-CWC mitigated UVB-induced dermal damage ex vivo by modulating key proteins and cytokines (p < 0.05).
  • In vivo studies showed increased collagen and elastin without thermal damage, with enhanced ECM remodeling in sliding mode.

Conclusions:

  • The RF-CWC system demonstrates significant efficacy and safety for facial rejuvenation.
  • It promotes robust ECM remodeling and neocollagenesis while minimizing inflammatory responses.
  • This technology represents an optimized and patient-friendly advancement in MRF facial treatments.