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Impact of Sema3A Interference on Cerebellum-Dependent Motor Associative Learning and Memory

Geoffrey-Alexander Gimenez1,2, Sarah Van Der Zwaag2, Cynthia M Geelen2

  • 1Department of Neuroregeneration, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.

International Journal of Molecular Sciences
|June 26, 2026
PubMed
Summary

Semaphorin 3A (Sema3A) in brain perineuronal nets (PNNs) impacts cerebellar memory. Impaired Sema3A signaling in K108N mice enhanced eyeblink conditioning performance, suggesting a role in learning.

Keywords:
cerebellar nucleieyeblink conditioningneuroplasticityperineuronal netssemaphorin 3A

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