Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential Effects of Low-Intensity Pulsed Ultrasound and Antifungals on <i>Candida albicans</i> and <i>Candida glabrata</i>: Implications for Drug Efficacy.

Journal of fungi (Basel, Switzerland)·2026
Same author

Correction: TSP50 facilitates breast cancer stem cell‑like properties maintenance and epithelial‑mesenchymal transition via PI3K p110α mediated activation of AKT signaling pathway.

Journal of experimental & clinical cancer research : CR·2026
Same author

In situ spatiotemporal tracking of endogenous protein dynamics with allosteric genetically encoded biosensor in living cells.

Biosensors & bioelectronics·2026
Same author

Corrigendum to "Enhanced electric field intensity in transverse microchannel charcoal electrode for facilitating electrochemical demulsification rate of oil-in-water droplets" [J Hazard Mater 511 (2026) 142186].

Journal of hazardous materials·2026
Same author

Fast food, fast aging? A cross-sectional study in the UK.

BMC public health·2026
Same author

Enhanced electric field intensity in transverse microchannel charcoal electrode for facilitating electrochemical demulsification rate of oil-in-water droplets.

Journal of hazardous materials·2026
Same journal

RETRACTED: Kim et al. The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Regulating the Visceral Adipose-Tissue Function. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 846.

International journal of molecular sciences·2026
Same journal

Correction: Mahmud et al. Thymoquinone Attenuates NF-κβ Signalling Activation in Retinal Pigment Epithelium Cells Under AMD-Mimicking Conditions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 11473.

International journal of molecular sciences·2026
Same journal

Correction: Borovikov et al. The Twisting and Untwisting of Actin and Tropomyosin Filaments Are Involved in the Molecular Mechanisms of Muscle Contraction, and Their Disruption Can Result in Muscle Disorders. <i>Int. J. Mol. Sci</i>. 2025, <i>26</i>, 6705.

International journal of molecular sciences·2026
Same journal

Correction: Molagoda et al. Flavonoid Glycosides from <i>Ziziphus jujuba</i> var. <i>inermis</i> (Bunge) Rehder Seeds Inhibit α-Melanocyte-Stimulating Hormone-Mediated Melanogenesis. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 7701.

International journal of molecular sciences·2026
Same journal

Correction: Guo et al. Integrated Transcriptomic and Metabolomic Analysis Reveals the Molecular Regulatory Mechanism of Flavonoid Biosynthesis in Maize Roots Under Lead Stress. <i>Int. J. Mol. Sci.</i> 2024, <i>25</i>, 6050.

International journal of molecular sciences·2026
Same journal

Correction: Chang et al. Improvement of Carbon Tetrachloride-Induced Acute Hepatic Failure by Transplantation of Induced Pluripotent Stem Cells Without Reprogramming Factor c-Myc. <i>Int. J. Mol. Sci.</i> 2012, <i>13</i>, 3598-3617.

International journal of molecular sciences·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
07:48

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

Published on: September 30, 2022

Radiolabeled Antimicrobials for Infection Imaging: A Scoping Review.

Sichen Liu1,2, James Townley3, Chuen-Yen Lau4

  • 1Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

International Journal of Molecular Sciences
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Radiolabeled antimicrobials show promise for infection imaging, but many lack specificity. While some tracers aid pharmacokinetic studies, challenges in background clearance and target-to-non-target ratios limit diagnostic use.

Keywords:
PET imagingin vivo PET imaginginfection imaginginfectious disease diagnosticsradiolabeled antimicrobials

More Related Videos

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
10:06

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence

Published on: February 26, 2018

4D Multimodality Imaging of Citrobacter rodentium Infections in Mice
12:38

4D Multimodality Imaging of Citrobacter rodentium Infections in Mice

Published on: August 13, 2013

Related Experiment Videos

Last Updated: Jun 27, 2026

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
07:48

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

Published on: September 30, 2022

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
10:06

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence

Published on: February 26, 2018

4D Multimodality Imaging of Citrobacter rodentium Infections in Mice
12:38

4D Multimodality Imaging of Citrobacter rodentium Infections in Mice

Published on: August 13, 2013

Area of Science:

  • Medical Imaging
  • Infectious Diseases
  • Pharmacology

Background:

  • Pathogen-specific imaging for infections is needed to improve clinical outcomes.
  • Antimicrobials, due to their target specificity, are potential molecular imaging ligands for infections.
  • No antimicrobial-based ligands are currently approved for clinical infection imaging.

Purpose of the Study:

  • To comprehensively survey radiolabeled antimicrobials across various drug classes.
  • To examine the translational progression of these agents from preclinical to clinical studies.
  • To identify agents with characteristics suitable for infection imaging.

Main Methods:

  • Scoping review of PubMed and Google Scholar (1970-2025) following PRISMA-ScR guidelines.
  • Independent screening of titles, abstracts, and full-text articles by two reviewers.
  • Data extraction and removal of duplicate content from 143 preclinical and 25 clinical articles.

Main Results:

  • Clinical studies showed suboptimal specificity for most tracers, though some aided pharmacokinetic characterization.
  • Preclinical studies identified radiolabeled plazomicin and echinocandins (caspofungin, anidulafungin) as promising.
  • Many radioligands had good tissue penetration but poor washout, limiting diagnostic value.

Conclusions:

  • Ideal antimicrobial properties for pharmacology may hinder imaging due to requirements for rapid clearance and high target-to-non-target ratios.
  • While in vivo pharmacokinetic applications are promising, significant challenges persist for effective infection imaging.
  • Further development is needed to overcome limitations in specificity and washout for clinical application.