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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: Jun 27, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

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Towards Sensitization Profiling for Allergy Prevention in Russia: A Systematic Review.

Alexandra Dubovets1,2, Anastasia Lukashevichus1, Valery Artemova1

  • 1Laboratory of Immunopathology, Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University, Moscow 119992, Russia.

International Journal of Molecular Sciences
|June 26, 2026
PubMed
Summary

Allergies affect 30% globally. This review found regional differences in Russia

Keywords:
IgE profileallergenallergic sensitizationpreventive allergen-specific immunizationrespiratory allergy

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Published on: May 31, 2021

Area of Science:

  • Immunology
  • Public Health
  • Environmental Medicine

Background:

  • Allergy is a common hypersensitivity disorder impacting 30% of the global population.
  • Rising allergy prevalence poses a significant public health challenge, necessitating improved diagnostics and treatments.
  • Preventive allergen-specific immunotherapy is a key research area for respiratory allergic diseases.

Purpose of the Study:

  • To systematically review IgE sensitization profiles across different regions of Russia.
  • To identify regional variations in allergen sensitization.
  • To propose a framework for future harmonized studies.

Main Methods:

  • Systematic database review adhering to PRISMA and SWiM guidelines.
  • Data synthesis from 60 studies on IgE sensitization in Russia.
  • Analysis of regional differences in allergen sensitization patterns.

Main Results:

  • Significant regional variations in IgE sensitization profiles were identified across Russia.
  • Methodological heterogeneity and evidence gaps were noted among the reviewed studies.
  • Current data are insufficient for reliable, region-specific allergy profiling.

Conclusions:

  • Understanding local IgE sensitization profiles is crucial for optimizing allergy management.
  • Further systematic and harmonized research is needed to develop region-tailored allergy approaches in Russia.
  • Addressing methodological inconsistencies is essential for accurate profiling.