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Myeloid-Derived Suppressor Cells in Inflammatory Arthritis.

Daniel R McDougle1,2, James J Moon2,3,4,5, David A Fox1

  • 1Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

International Journal of Molecular Sciences
|June 26, 2026
PubMed
Summary

Myeloid-derived suppressor cells (MDSCs) have complex roles in inflammatory arthritis, potentially worsening or alleviating disease. Their function depends heavily on context, influencing therapeutic strategies.

Keywords:
cytokine signalingimmune regulationinflammatory arthritismyeloid plasticitymyeloid-derived suppressor cellsrheumatoid arthritis

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14:15

Preparation of Myeloid Derived Suppressor Cells (MDSC) from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting (AutoMACS)

Published on: June 18, 2012

Area of Science:

  • Immunology
  • Rheumatology
  • Cell Biology

Background:

  • Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with immunosuppressive functions.
  • MDSCs accumulate in chronic inflammation, particularly in inflammatory arthritis models.
  • Their role in arthritis was initially considered regulatory but is now known to be complex.

Purpose of the Study:

  • To review the current understanding of MDSCs in inflammatory arthritis.
  • To explore the factors influencing MDSC functional diversity and impact on disease.
  • To discuss emerging therapeutic strategies targeting MDSCs in arthritis.

Main Methods:

  • Literature review of studies on MDSCs in rheumatoid arthritis and experimental arthritis models.
  • Analysis of factors influencing MDSC immunophenotype, function, and disease outcomes.
  • Synthesis of current knowledge on MDSC plasticity and context-dependent roles.

Main Results:

  • MDSC function in arthritis is highly context-dependent, influenced by immunophenotype, disease stage, and microenvironment.
  • MDSCs can either alleviate or exacerbate inflammatory arthritis.
  • The diverse roles suggest a plastic myeloid continuum rather than a single function.

Conclusions:

  • MDSC activity in inflammatory arthritis is multifaceted and highly plastic.
  • Understanding the context-specific roles of MDSCs is crucial for developing effective therapies.
  • Further research into MDSC plasticity and therapeutic targeting is warranted.