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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
Published on: April 12, 2021
Vitamin D3 and Body Composition Association with Graft Function in Long-Term Kidney Transplant Recipients
Maksymilian Hryciuk1, Zbigniew Heleniak1, Sylwia Małgorzewicz1,2
1Department of Nephrology, Medical University of Gdańsk, Dębinki 7 Street, 80-211 Gdańsk, Poland.
International Journal of Molecular Sciences
|June 26, 2026
Summary
Vitamin D3 levels did not correlate with kidney transplant function or body composition in stable recipients. This study found no significant association between vitamin D status and graft outcomes.
Area of Science:
- Nephrology
- Endocrinology
- Transplantation
Background:
- Vitamin D is crucial for bone health and immune function.
- Renal transplant recipients often have altered vitamin D metabolism.
- The relationship between vitamin D status, graft function, and body composition requires further investigation.
Purpose of the Study:
- To evaluate the association between 25(OH)D3 levels, kidney transplant function (eGFR), and body composition.
- To explore correlations with clinical and metabolic parameters in stable renal transplant recipients.
Main Methods:
- Cross-sectional study of 315 stable renal transplant recipients.
- Biochemical analysis included eGFR, PTH, calcium, phosphorus, and 25(OH)D3.
- Body composition assessed using bioelectrical impedance analysis (BMI, visceral fat, phase angle).
- Multivariable quantile regression models were employed.
Main Results:
- 25(OH)D3 levels did not correlate with graft function (eGFR) in the overall population.
- No significant differences in eGFR were found across vitamin D status categories (deficiency, insufficiency, optimal).
- 25(OH)D3 levels significantly correlated only with calcium levels, not with transplant vintage, age, eGFR, or body composition parameters.
Conclusions:
- Vitamin D3 status does not appear to be a significant determinant of graft function or body composition in stable renal transplant recipients.
- Further research may be needed to understand the complex interplay of factors affecting transplant outcomes.
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