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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

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Updated: Jun 27, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
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Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

Gestodene Accelerates Cutaneous Wound Healing via PAR1-Selective Positive Allosteric Modulation.

Hyejin Jeon1, Yunkyung Heo1, Yechan Lee1

  • 1College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Republic of Korea.

International Journal of Molecular Sciences
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Gestodene, a PAR1-selective positive allosteric modulator, accelerates wound healing by enhancing cell proliferation and collagen deposition. This study highlights gestodene

Keywords:
PAR1migrationpositive allosteric modulatorproliferationwound repair

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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

Area of Science:

  • Pharmacology
  • Dermatology
  • Cell Biology

Background:

  • Protease-activated receptor 1 (PAR1) is crucial for cutaneous wound healing processes.
  • Limited availability of PAR1-selective positive allosteric modulators (PAMs) hinders therapeutic development.

Purpose of the Study:

  • To investigate the wound healing efficacy of gestodene, a selective PAR1 PAM.
  • To elucidate the mechanism of gestodene's action in wound repair.

Main Methods:

  • Characterized gestodene's effect on PAR1-activating peptide (PAR1-AP)-induced calcium signaling in human keratinocytes and dermal fibroblasts.
  • Assessed gestodene's impact on PAR1-dependent cell proliferation, migration, and ERK1/2 activation.
  • Evaluated gestodene's efficacy in a murine wound model following topical administration.

Main Results:

  • Gestodene selectively potentiated PAR1 signaling without intrinsic agonist activity.
  • Gestodene enhanced PAR1-dependent cell proliferation, migration, and expression of wound healing genes (MMPs, fibronectin, collagen).
  • Topical gestodene accelerated wound closure and collagen deposition in mice, with effects reversed by PAR1 inhibition.

Conclusions:

  • Gestodene accelerates cutaneous wound healing via PAR1-selective positive allosteric modulation.
  • Gestodene shows potential as a drug repositioning candidate for wound repair therapies.