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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Related Experiment Video

Updated: Jun 27, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Shared Transcriptomic Signatures and Network Interactions Between Lung Adenocarcinoma and Asthma.

Seha Akduman1, Elif Düz2, Merve Gündoğdu2,3

  • 1Department of Pulmonary Diseases, School of Medicine, Yeditepe University, Istanbul 34755, Türkiye.

International Journal of Molecular Sciences
|June 26, 2026
PubMed
Summary

This study reveals shared molecular mechanisms between lung adenocarcinoma (LUAD) and asthma, identifying key genes like DNAJC3, APOBEC3G, and PRDX4. These findings suggest potential for drug repurposing in treating both diseases.

Keywords:
asthmaco-expression networklung adenocarcinoma (LUAD)protein interaction network (PPI)transcriptome

Related Experiment Videos

Last Updated: Jun 27, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Area of Science:

  • Pulmonary Medicine
  • Genomics
  • Computational Biology

Background:

  • Lung adenocarcinoma (LUAD) is a leading cause of cancer mortality.
  • Asthma is a widespread chronic respiratory disease.
  • Both conditions involve airway inflammation and oxidative stress, suggesting shared risk factors and genetic links.

Purpose of the Study:

  • To investigate molecular mechanism similarities between LUAD and asthma.
  • To identify shared transcriptomic signatures.
  • To explore potential drug repurposing opportunities based on common pathways.

Main Methods:

  • Analysis of transcriptomic datasets for asthma and LUAD.
  • Identification of shared genes and co-expression interactions.
  • Highlighting potential common molecular mediators.

Main Results:

  • A set of genes and co-expression interactions common to both asthma and LUAD was identified.
  • DNAJC3, APOBEC3G, and PRDX4 were identified as potential common molecular mediators.
  • Correlative evidence supports shared pathways and molecular links between the diseases.

Conclusions:

  • Shared molecular mechanisms and transcriptomic signatures exist between asthma and LUAD.
  • Identified genes may serve as key molecular links in disease pathogenesis.
  • Findings provide a computational framework for future therapeutic association and drug-gene relationship studies.