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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Updated: Jun 27, 2026

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
07:12

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Published on: November 24, 2020

Building Disease Models for Endometriosis: iPSCs as Game-Changers.

Khalisa H Kahar1, Bushra E-Anjum1, Fazlina Nordin1

  • 1Department of Tissue Engineering and Regenerative Medicine (DTERM), Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia.

International Journal of Molecular Sciences
|June 26, 2026
PubMed
Summary

Patient-derived induced pluripotent stem cell (iPSC) models offer promising avenues for understanding endometriosis. These models advance personalized medicine and therapeutic discovery for this widespread gynecological condition.

Keywords:
disease modellingdrug screeningendometriosisinduced pluripotent stem cellpatient-derived modelspersonalized medicine

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Published on: January 6, 2012

Area of Science:

  • Gynecology
  • Stem Cell Biology
  • Disease Modeling

Background:

  • Endometriosis affects 176 million women globally, causing pain, infertility, and increased cancer risk.
  • Characterized by endometrial-like tissue outside the uterus, it involves inflammation and fibrotic tissue formation.
  • Current understanding necessitates advanced models for personalized treatment strategies.

Purpose of the Study:

  • To evaluate the potential of endometriosis models, particularly patient-derived induced pluripotent stem cell (iPSC) models.
  • To enhance insights into endometriosis pathogenesis and guide therapeutic development.
  • To bridge traditional anatomical classifications with modern molecular modeling approaches.

Main Methods:

  • Comprehensive narrative review of PubMed, Scopus, and Web of Science databases (Jan 2000 - May 2025).
  • Extensive search using keywords: endometriosis, iPSCs, organoids, disease modeling, epigenetics.
  • Analysis of over 170 peer-reviewed publications, including genomic studies and 3D culture systems.

Main Results:

  • Patient-derived iPSC models show significant potential for disease modeling.
  • These models can mimic patient-specific endometrial tissue and lesions.
  • Integration of genomic data with advanced culture systems offers new insights.

Conclusions:

  • iPSC platforms are crucial for advancing personalized medicine in endometriosis.
  • These models facilitate deeper understanding and accelerate therapeutic discovery.
  • Future research should leverage iPSC technology for targeted endometriosis treatments.