Related Experiment Video
Updated: Jun 27, 2026

Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases
Published on: November 18, 2013
A Functional SNP in the AMH Gene Is Associated with Litter Size in Dazu Black Goats
Lei Wang1, Yiyu Zhang1, Qiuyan Li1
1Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Abstract:
AMH plays a critical role in ovarian follicular development and may influence reproductive performance. However, its genetic variation and association with litter size in goats remain unclear. In this study, three single-nucleotide polymorphisms (SNPs) in the AMH gene (g.89169447C>A, g.89169684G>A, and g.89170008T>C) were identified in Dazu Black goats. Association analysis showed that the g.89169447C>A locus was significantly associated with litter size at first parity (p < 0.05), while the g.89169684G>A locus was significantly associated with the average litter size across the first three parities (p < 0.05). Functional assays in granulosa cells indicated that the g.89169684G>A variant altered the expression of proliferation and apoptosis-related genes. These results suggest that the g.89169684G>A variant may serve as a potential molecular marker for improving reproductive performance in goats.
Related Concept Videos
Epistasis
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Lethal Alleles
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Epistasis Analysis
Incomplete Dominance

