Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Coronavirus

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dynamic monitoring of rice plant height during the early growth stage using UAV-LiDAR and GWAS analysis of growth rate.

Frontiers in plant science·2026

Same author

NanoporeDB: A Structural Resource Of Multimeric Protein Nanopores For Single-Molecule Sensing.

GigaScience·2026

Same author

<i>Echinacea purpurea</i> polysaccharides regulate the intestinal microbiota and enhance immune function in broilers.

Animal nutrition (Zhongguo xu mu shou yi xue hui)·2026

Same author

Development of super Vδ2 T cells for relapsed/refractory acute myeloid Leukemia via non-viral site-specific integration.

International immunopharmacology·2026

Same author

Exploring Chiral Exceptional Lines in the Visible Regime.

Physical review letters·2026

Same author

Network Toxicology and Transcriptomic Analyses Reveal Ferroptosis-Related Neurotoxicity of Rotenone as an Environmental Hazardous Compound.

Cells·2026

Same journal

Correction: Gernhardt et al. Ex Vivo Computed Tomographic Morphometry and Motion of the Native and Fractured Equine Accessory Carpal Bone. <i>Animals</i> 2026, <i>16</i>, 1132.

Animals : an open access journal from MDPI·2026

Same journal

Camera-Trap Assessment of Terrestrial Mammals and Ground-Dwelling Birds in the Zhangjiajie Chinese Giant Salamander National Nature Reserve, China.

Animals : an open access journal from MDPI·2026

Same journal

Beyond the Mission: Long-Term Endocrine Dynamics in Search and Rescue Dog-Handler Teams.

Animals : an open access journal from MDPI·2026

Same journal

Phenotypic Characterisation of the Abruzzo Donkey (<i>Equus asinus</i>), an Endangered Italian Genetic Resource: Body Measurements.

Animals : an open access journal from MDPI·2026

Same journal

Assessment of Maternal Genetic Diversity and Mitochondrial Population Structure of Endangered Indigenous Chicken Breeds in China.

Animals : an open access journal from MDPI·2026

Same journal

Effects of Expected Progeny Difference and Feeding Systems on Carcass Characteristics in Hanwoo Steers.

Animals : an open access journal from MDPI·2026

See all related articles

Search research articles

Home
Notoginsenoside R1 Inhibits Porcine Deltacoronavirus Infection In Vitro By Restoring Serca2-mediated Calcium Homeostasis.

Home
Notoginsenoside R1 Inhibits Porcine Deltacoronavirus Infection In Vitro By Restoring Serca2-mediated Calcium Homeostasis.

Related Experiment Video

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction

Published on: May 17, 2024

Notoginsenoside R1 Inhibits Porcine Deltacoronavirus Infection In Vitro by Restoring SERCA2-Mediated Calcium

Jialu Zhang¹, Yuqian Liu¹, Wenzhe Liu¹

¹Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China.

Animals : an Open Access Journal From MDPI

|June 26, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Notoginsenoside R1 (NG-R1) effectively combats porcine coronavirus (PDCoV) by restoring calcium balance and reducing ER stress. This natural compound shows promise as a novel antiviral agent for swine health.

Keywords:

Notoginsenoside R1 cellular calcium ions endoplasmic reticulum porcine deltacoronavirus

More Related Videos

Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators

Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators

Published on: January 19, 2024

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Related Experiment Videos

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction

A Seamless Cloning Approach for Porcine Reproductive and Respiratory Syndrome Virus Expression Vector Construction

Published on: May 17, 2024

Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators

Live Calcium Imaging of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators

Published on: January 19, 2024

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Area of Science:

Veterinary Virology
Natural Product Chemistry
Molecular Pharmacology

Background:

Porcine coronavirus (PDCoV) causes significant economic losses in the pig industry due to severe diarrhea in piglets.
Current antiviral strategies against PDCoV are limited, necessitating the exploration of new therapeutic agents.

Purpose of the Study:

To investigate the antiviral effects of Notoginsenoside R1 (NG-R1) against PDCoV.
To elucidate the underlying molecular mechanisms of NG-R1's antiviral activity.

Main Methods:

Cell viability assays using LLC-PK1 cells.
Network pharmacology analysis to identify potential pathways.
Intracellular calcium level measurements and endoplasmic reticulum (ER) stress assessment.
Analysis of SERCA2 expression and functional assays with SERCA2 inhibitor.

Main Results:

NG-R1 demonstrated no cytotoxicity and inhibited PDCoV replication throughout its life cycle.
PDCoV infection disrupted calcium homeostasis and induced ER stress, which NG-R1 partially reversed.
NG-R1 modulated SERCA2 expression, and SERCA2 inhibition mimicked NG-R1's antiviral effect.

Conclusions:

NG-R1 possesses significant antiviral activity against PDCoV.
The mechanism involves the regulation of intracellular calcium homeostasis via SERCA2, thereby attenuating ER stress.
NG-R1 represents a potential therapeutic candidate for PDCoV infections, targeting calcium signaling pathways.