Related Experiment Video

Updated: Jun 27, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Notch Overexpression Potentiates Interferon Signaling in Glioma Cells

Marina Giannaki1, Elena Parmigiani1, Karin Burger1

  • 1Embryology and Stem Cell Biology, Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

Current Issues in Molecular Biology
|June 26, 2026
PubMed
Summary

Activating the Notch pathway enhances interferon (IFN) signaling in glioma cells, boosting anti-tumor immunity. This approach promotes cytotoxic T lymphocyte recruitment and reduces tumor growth, offering a new strategy for glioma treatment.

Keywords:
brain tumorgliomainterferon signalingnotch signaling

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The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

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