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Olive Leaf Extract Suppresses Sebogenesis and Inflammation via AKT/ERK and SREBP-1/PPAR-γ Signaling in Human

Jeeyoung Kim1, Ye-Won Jo2, Weon Jeong Bang1

  • 1Research and Development Center, Durae Corporation, Anyang Trade Center 14F, 161, Simin-daero, Dongan-gu, Anyang 14048, Gyeonggi-do, Republic of Korea.

Current Issues in Molecular Biology
|June 26, 2026
PubMed

Insights

Olive leaf extract (OLE) effectively reduces skin oil production and inflammation in vitro. Its key compound, oleuropein, shows similar benefits, suggesting potential for acne-prone skin treatments.

Area of Science:

  • Dermocosmetics
  • In vitro skin models
  • Phytochemistry

Background:

  • Oily and acne-prone skin conditions are linked to sebum production and inflammation.
  • Olive leaf extract (OLE) is explored for its potential dermatological benefits.
  • Understanding OLE's mechanism against sebum and inflammation is crucial.

Purpose of the Study:

  • To evaluate olive leaf extract (OLE) as a dermocosmetic candidate for oily and acne-prone skin.
  • To investigate OLE's effects on sebocyte lipogenesis, keratinocyte inflammation, and fibroblast activity.
  • To elucidate the molecular mechanisms underlying OLE's sebum-regulatory and anti-inflammatory actions.

Main Methods:

  • In vitro assays using SEB-1 sebocytes, HaCaT keratinocytes, and dermal fibroblasts.
  • Assessment of lipogenesis, inflammatory mediator production (IL-8, TNF-α, PGE2), and collagen gel contraction.
  • Analysis of signaling pathways including PPAR-γ, SREBP-1, AKT, and ERK phosphorylation.

Main Results:

  • OLE significantly inhibited sebocyte lipid accumulation without cytotoxicity.
  • OLE reduced pro-inflammatory cytokine production in keratinocytes induced by Cutibacterium acnes or UVB.
  • OLE enhanced fibroblast-mediated collagen gel contraction and downregulated key lipogenic and inflammatory signaling pathways.

Conclusions:

  • Olive leaf extract (OLE), particularly its 70% ethanol extract (OLE70), demonstrates multifunctional dermocosmetic potential.
  • OLE and its constituent oleuropein modulate sebum production, inflammation, and dermal remodeling.
  • Findings support OLE and oleuropein as candidates for further investigation in oily and acne-prone skin management.
Keywords:
Cutibacterium acnesPPAR-γSREBP-1collagen gel contractiondermal remodelinginflammationoleuropeinolive leaf extractsebum regulation

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