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Application of Unsupervised Multi-Omic Factor Analysis to Uncover Patterns of Variation and Molecular Processes Linked to Cardiovascular Disease
08:51

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Research Progress on Coronary Artery Injury and Myocardial Ischemia in Multisystem Inflammatory Syndrome in Children

Jirong Liu1, Nanyan Mao1, Yaru Cui1

  • 1National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.

Current Issues in Molecular Biology
|June 26, 2026
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C) is a severe condition following SARS-CoV-2 infection. Early diagnosis and management of MIS-C cardiovascular complications are crucial for improving long-term outcomes.

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Immunology

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a serious complication of SARS-CoV-2 infection.
  • Cardiovascular involvement, including coronary artery injury and myocardial dysfunction, is a hallmark of MIS-C.
  • These cardiovascular issues significantly impact disease severity and patient prognosis.

Purpose of the Study:

  • To review the immunopathological features and clinical presentations of MIS-C-associated coronary artery lesions.
  • To elucidate the pathophysiological mechanisms underlying MIS-C-induced myocardial ischemia.
  • To summarize current diagnostic, risk stratification, management, and follow-up strategies for MIS-C.

Main Methods:

  • Literature review of recent clinical and translational research on MIS-C.
  • Synthesis of evidence on immunopathology, clinical manifestations, and management approaches.
  • Focus on coronary artery abnormalities and myocardial ischemia.

Main Results:

  • MIS-C frequently causes coronary artery dilation and aneurysm formation.
  • Myocardial ischemia is a significant concern, linked to disease severity.
  • Current evidence guides diagnosis, risk assessment, and treatment protocols.

Conclusions:

  • Understanding MIS-C's cardiovascular impact is vital for effective patient care.
  • Timely intervention and optimized management are key to improving long-term cardiovascular health in affected children.
  • This review provides guidance for clinicians managing MIS-C patients.

Keywords:
coronary artery aneurysmcoronary artery injuryinflammatory stormmultisystem inflammatory syndrome in children (MIS-C)myocardial ischemia

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