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Long-term Monitoring of Oxygen Consumption Rates in Highly Differentiated and Polarized Retinal Pigment Epithelial Cultures
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Photoreceptor Vulnerability to Ferroptosis: Membrane Phospholipid Peroxidation, Mitochondrial Homeostasis, and

Yue Sun1, Zhaorui Xu1, Yanxia Wu1

  • 1Eye School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Current Issues in Molecular Biology
|June 26, 2026
PubMed
Summary

Photoreceptor degeneration involves ferroptosis, a cell death linked to lipid peroxidation. This review explores how photoreceptor vulnerability arises from their unique biochemistry and metabolic connections with the retinal pigment epithelium.

Keywords:
RPE–PR couplingferroptosislipid peroxidationmitochondrial homeostasisphotoreceptorspolyunsaturated fatty acidsretinal pigment epithelium

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