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Exploring the Relationship Between Protein-Level Ratios (rQLTs) and Duodenal Ulcer
Siwen Tang1, Yongwei Li1, Xi Yu1
1Faculty of Medicine, Macau University of Science and Technology, Taipa, Macao 999078, China.
Current Issues in Molecular Biology
|June 26, 2026
Summary
Genetic analysis revealed that higher protein-level ratios of Angiotensin-converting enzyme 2/γ-glutamyl transpeptidase 1 (ACE2/GGT1) are inversely associated with duodenal ulcer risk in East Asian populations.
Area of Science:
- Genetics
- Gastroenterology
- Epidemiology
Background:
- Duodenal ulcer (DU) risk is influenced by genetic and environmental factors.
- Understanding the molecular underpinnings of DU is crucial for risk assessment.
Purpose of the Study:
- To investigate the association between protein-level ratios (rQLTs) and duodenal ulcer (DU) risk.
- To identify potential molecular targets and genetic associations using advanced analytical methods.
Main Methods:
- Utilized bidirectional Mendelian randomization (MR) for causal inference.
- Employed inverse variance weighted (IVW) method and colocalization analysis.
- Constructed gene interaction networks and identified hub-genes using STRING and Cytoscape.
Main Results:
- A significant inverse genetic association was observed between rQLT-ACE2/GGT1 and DU risk in the East Asian (Japanese) population (IVW OR = 0.754).
- No statistically significant association was found in the European population.
- Findings suggest a population-specific genetic link rather than a universal causal relationship.
Conclusions:
- Protein-level ratios of ACE2/GGT1 show a genetic inverse association with DU risk in East Asians.
- The observed association lacks causality and requires further validation.
- Current findings do not support diagnostic or therapeutic applications for rQLT-ACE2/GGT1 in DU.
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