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Probiotics

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...

Microbiota Modulation by Antibiotics

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

Introduction to the Human Microbiota

Introduction to the Human Microbiota

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Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

Development of Human Microbiota

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Related Experiment Video

Updated: Jun 27, 2026

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Published on: September 10, 2016

From Laboratory to Real Clinical Practice: A Multidisciplinary Approach Towards the Next Probiotics.

Matteo Pavoni¹, Giulia Fiorini², Ilaria Maria Saracino¹

¹Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.

Antibiotics (Basel, Switzerland)

|June 26, 2026

Summary

This summary is machine-generated.

Genomic analysis confirmed the safety of new probiotics for Helicobacter pylori eradication. These probiotics, lacking transferable resistance elements, show promise in improving treatment adherence and outcomes.

Keywords:

Helicobacter pylori eradication therapy probiotics sequencing

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Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Published on: February 7, 2025

Related Experiment Videos

Last Updated: Jun 27, 2026

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Novel Production Protocol for Small-scale Manufacture of Probiotic Fermented Foods

Published on: September 10, 2016

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Published on: February 7, 2025

Area of Science:

Microbiology
Genomics
Gastroenterology

Background:

Helicobacter pylori infection causes gastritis and ulcers.
Antibiotic resistance and adverse effects hinder H. pylori eradication.
Probiotics may improve treatment adherence and tolerability.

Purpose of the Study:

Assess the genomic safety of novel probiotic strains.
Evaluate probiotics for adjuvant therapy in H. pylori eradication.

Main Methods:

Whole-genome sequencing of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis strains.
Comparative genomic analysis against wild-type strains.
Detection of genetic variations and mobile genetic elements.

Main Results:

Identified genetic differences between probiotic and wild-type strains.
Confirmed absence of plasmids and transposons.
Genomic data aligned with in vitro phenotypic results.

Conclusions:

Whole-genome sequencing robustly assessed probiotic safety.
Absence of transferable resistance elements supports probiotic use.
Potential to enhance H. pylori eradication therapy adherence and efficacy.