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Related Experiment Video

Updated: Jun 27, 2026

Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro
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Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro

Published on: March 21, 2015

Oxidative Stress in Migraine-Effect or Cause?

Oliwia Szymanowicz1,2, Bartosz Słowikowski3, Mateusz Konieczny1,4

  • 1Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.

Genes
|June 26, 2026
PubMed
Summary

Oxidative stress, an imbalance in the body, is increasingly linked to migraine development. This review explores its role in migraine pathogenesis, genetics, and potential bidirectional relationships.

Keywords:
environmental factorsmigrainemolecular markersoxidative stresspathophysiology

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Area of Science:

  • Neuroscience
  • Genetics
  • Biochemistry

Background:

  • Migraine is a complex neurovascular disorder with multifactorial causes.
  • Oxidative stress, an imbalance between reactive oxygen species and antioxidant defenses, is implicated in migraine pathogenesis.
  • The precise role of oxidative stress—causal or consequential—in migraine remains under investigation.

Purpose of the Study:

  • To review current evidence on the role of oxidative stress in migraine.
  • To discuss the relationship between oxidative stress and molecular/genetic mechanisms in migraine.
  • To explore how genetic factors influence susceptibility and variability in migraine presentation.

Main Methods:

  • Literature review of studies on oxidative stress and migraine.
  • Analysis of genetic factors (e.g., SOD2, GPX1, CAT, CALCA) in relation to oxidative stress and migraine.
  • Examination of molecular pathways including mitochondrial function and neuroinflammation.

Main Results:

  • Elevated markers of oxidative damage and altered antioxidant enzyme activity are observed in migraine patients.
  • Metabolic and inflammatory changes associated with migraine may exacerbate oxidative imbalance, suggesting a bidirectional relationship.
  • Specific genes (SOD2, GPX1, CAT) influence susceptibility to oxidative stress and migraine; CALCA links oxidative stress to neurogenic inflammation.

Conclusions:

  • Oxidative stress is a significant factor in migraine pathophysiology, contributing to neuronal hyperexcitability, mitochondrial dysfunction, and neuroinflammation.
  • A bidirectional relationship likely exists between oxidative stress and migraine-related processes.
  • Genetic factors play a crucial role in individual susceptibility and clinical variability of migraine, particularly those involved in oxidative pathways.