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Updated: Jun 27, 2026
07:20
Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
Ocular Alignment and Strabismus-Related Findings Associated with Low-Dose Atropine for Myopia Control in Children: A
Yo Iwata1, Tomoya Handa1, Hitoshi Ishikawa1
1Department of Rehabilitation, Orthoptics and Visual Science Course, School of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara 252-0373, Japan.
Children (Basel, Switzerland)
|June 26, 2026
Summary
Low-dose atropine eye drops effectively control myopia in children but may rarely cause eye alignment issues. Careful monitoring is advised for children with unstable binocular vision, especially during dose increases.
Area of Science:
- Ophthalmology
- Pediatric Optometry
- Clinical Research
Background:
- Low-dose atropine is a common treatment for slowing myopia progression in children.
- Potential impacts on ocular alignment and binocular vision due to atropine's effect on accommodation require synthesis.
Purpose of the Study:
- To review existing evidence on the relationship between low-dose atropine for pediatric myopia control and ocular alignment/strabismus findings.
- To synthesize data on potential adverse effects on binocular vision.
Main Methods:
- Systematic literature search of PubMed/MEDLINE and Web of Science Core Collection.
- Screening of English-language studies on low-dose atropine, myopia control, ocular alignment, strabismus, and binocular vision.
- Inclusion of 11 studies (6 clinical/interventional, 5 case reports/series).
Main Results:
- Case reports indicated potential for esodeviation, convergence excess, and acquired esotropia, often resolving post-treatment modification.
- Clinical studies did not consistently show worsening of ocular alignment, NPC, or fusional vergence.
- Consistent findings included mydriasis, reduced accommodative function, and temporary binocular fluctuations.
Conclusions:
- Low-dose atropine is generally safe and effective for pediatric myopia control.
- Selected cases may exhibit transient ocular alignment or strabismus issues.
- Monitoring is recommended for children with pre-existing binocular instability or during atropine dose escalation.
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