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Related Experiment Video

Updated: Jun 27, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

Cross-Category Screening of Food Samples for Amyloid-β42 Aggregation-Inhibitory Activity Using a Microliter-Scale

Kota Nakamura1, Manae Kawamura-Yamagishi1, Masahiro Kuragano1

  • 1Graduate School of Engineering, Muroran Institute of Technology, 27-1 Mizumoto-cho, Muroran 050-8585, Hokkaido, Japan.

Foods (Basel, Switzerland)
|June 26, 2026
PubMed
Summary

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Researchers screened 120 food samples for Alzheimer

Area of Science:

  • Neuroscience and Food Science
  • Investigating molecular mechanisms of neurodegenerative diseases
  • Exploring natural product chemistry for therapeutic applications

Background:

  • Alzheimer's disease (AD) pathogenesis involves amyloid-beta (Aβ) aggregation.
  • Food-derived compounds are potential modulators of Aβ-related processes.
  • Direct effects of diverse food samples on Aβ42 aggregation require clarification.

Purpose of the Study:

  • To screen a wide range of food samples for inhibitory activity against Aβ42 aggregation.
  • To identify specific food items that can modulate Aβ42 aggregation.
  • To provide a foundation for functional food research targeting Alzheimer's disease.

Main Methods:

  • Screened 120 food preparations using an automated high-throughput system with quantum-dot-labeled Aβ (QDAβ).
Keywords:
Alzheimer’s diseaseAβ aggregation inhibitorQDAβamyloid-β42food screeningfunctional food

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  • Validated hits using thioflavin T (ThT) assays and transmission electron microscopy (TEM).
  • Assessed the impact of selected food samples on cell viability in Aβ42-treated PC12 cells.

    • Main Results:

    • 34 out of 120 samples showed Aβ42 aggregation inhibitory activity; 12 were highly active.
    • Tea-related samples, black tea, Camembert, red perilla, and black soybean were identified as potent inhibitors.
    • Inhibitory effects were concentration-dependent, confirmed by ThT assays and TEM, and improved cell viability.

    Conclusions:

    • Certain food-derived components, particularly from tea, effectively inhibit Aβ42 aggregation.
    • This study validates the potential of functional foods in modulating Alzheimer's disease-related processes.
    • Findings support further research into identifying and isolating active components from these food sources.