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Food-Grade Microemulsion for High-Loading Octacosanol: Formulation Optimization, Characterization, and Biological

Jiayi Lin¹, Shengang Yao¹, Lanlan Li¹

¹College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China.

Foods (Basel, Switzerland)

|June 26, 2026

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A novel food-grade microemulsion effectively delivers octacosanol (OCT) in beverages. This system overcomes poor solubility and low loading issues, enhancing OCT

Area of Science:

Food Science and Technology
Biomaterials Engineering
Nutraceutical Delivery Systems

Background:

Octacosanol (OCT) is a bioactive compound with health benefits but limited use in beverages due to poor water solubility.
Existing OCT delivery systems face challenges with low loading efficiency and high emulsifier concentrations.

Purpose of the Study:

To develop a food-grade microemulsion (ME) for enhanced octacosanol (OCT) delivery in functional beverages.
To achieve a high loading capacity for OCT in the microemulsion system.

Main Methods:

Formulation optimization using pseudo-ternary phase diagrams and analysis of particle size and polydispersity index (PDI).
Characterization of the optimized OCT-loaded microemulsion (OCT-ME), including stability and gastric protection.

Keywords:

biocompatibility functional beverage in vitro digestion microemulsion octacosanol stability

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Evaluation of the biocompatibility of the developed OCT-ME system.

Main Results:

An optimal OCT-ME formulation was achieved with 1.0% OCT loading capacity.
The resulting OCT-ME exhibited a small particle size (10.37 nm), low PDI, and excellent stability.
The formulation demonstrated favorable gastric OCT protection and high biocompatibility (cell viability > 90%).

Conclusions:

The developed food-grade OCT-ME effectively addresses limitations of previous delivery systems.
This microemulsion provides a promising solution for incorporating OCT into functional beverages.
The study offers theoretical support for efficient OCT solubilization and delivery.