Clinical Outcomes Associated with a Propolis-Based Nano-Formulated Bioadhesive Oral Gel: A Retrospective Case Series...

Area of Science:

• Oral Medicine
• Periodontology
• Nanotechnology in Therapeutics

Background:

• Propolis-based nano-formulated bioadhesive oral gel (NBF gel) with vitamins C and E is a proposed supportive therapy for oral mucosal lesions.
• Long-term clinical data and adjunctive effects on periodontal status in specific populations are needed.

Purpose of the Study:

• Evaluate clinical outcomes of NBF gel for oral mucosal conditions over 15 years.
• Assess the adjunctive effect of NBF gel on periodontal status in patients with intellectual disabilities.

Main Methods:

• Retrospective observational case series of 295 patients with various oral mucosal conditions treated with NBF gel.
• Non-randomized controlled clinical study involving 40 patients with intellectual disabilities comparing toothbrushing alone versus toothbrushing with NBF gel.

Main Results:

• NBF gel treatment was successful in 89.8% of patients with oral mucosal conditions, with better outcomes for inflammatory and post-treatment lesions.
• Adjunctive NBF gel application significantly improved periodontal status compared to toothbrushing alone in patients with intellectual disabilities.
• No clinically relevant adverse effects were reported, though safety monitoring was limited.

Conclusions:

• The nano-formulated bioadhesive oral gel may be a useful adjunctive topical therapy for specific oral mucosal and periodontal conditions.
• Further randomized controlled studies with standardized outcome measures are necessary to validate these preliminary findings.