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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Multifunctional 3D-Printed Alginate Emulgel Patches Incorporating Plant Extracts for Potential Burn Wound

Roxana Colette Sandulovici1, Ion Mircioiu1, Mariana Panțuroiu1

  • 1Faculty of Pharmacy, Titu Maiorescu University, 040314 Bucharest, Romania.

Gels (Basel, Switzerland)
|June 26, 2026
PubMed
Summary

3D-printed alginate emulgel patches containing plant extracts were developed for burn wound management. These novel dressings offer moisture regulation, antioxidant properties, and good biocompatibility, showing promise for topical wound care.

Keywords:
3D printingHaCaT cellsalginateantioxidant activityburn wound applicationsburn wound dressingemulgelplant extractspolyphenols

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Area of Science:

  • Biomaterials Science
  • Wound Healing Research
  • Drug Delivery Systems

Background:

  • Advanced wound dressings are crucial for burn management, requiring multifunctionality.
  • Maintaining a moist environment and delivering bioactive agents are key.
  • Alginate-based systems offer potential for enhanced wound healing.

Purpose of the Study:

  • To develop and characterize 3D-printed alginate emulgel patches for burn wound applications.
  • To incorporate hydrophilic and lipophilic plant extracts for enhanced therapeutic effects.
  • To evaluate the physicochemical, structural, functional, and biological properties of the developed patches.

Main Methods:

  • Extrusion-based 3D printing of alginate emulgels with plant extracts (Calendula officinalis, Matricaria chamomilla, Plantago major, Hippophae rhamnoides, Hypericum perforatum).
  • Characterization of emulgel and patches: pH, rheology, stability, particle size, zeta potential, polyphenol content, antioxidant activity, swelling, water vapor transmission rate (WVTR).
  • In vitro release studies of polyphenols and cell viability assays (HaCaT cells).

Main Results:

  • Successfully fabricated uniform, flexible 3D-printed alginate emulgel patches with suitable printing characteristics.
  • Patches demonstrated good dimensional stability, flexibility, swelling capacity, and appropriate WVTR for moisture regulation.
  • Confirmed retention of bioactive polyphenols with significant antioxidant activity and sustained release over 24 hours.
  • Demonstrated excellent biocompatibility with HaCaT cells, maintaining over 90% viability at tested concentrations.

Conclusions:

  • 3D-printed alginate emulgel patches incorporating diverse plant extracts are promising multifunctional systems for burn wound management.
  • The developed dressings offer a combination of moisture regulation, bioactive compound delivery, and antioxidant properties.
  • Further preclinical investigations are warranted to validate the therapeutic potential of these advanced wound care systems.