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Postbiotics as Multifunctional Bioactives: Mechanistic Insights and Translational Applications in Host Physiology and
Nidhisha Babysulatha Sasidharan1, Sreetha Hely1, Subin John1
1School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, Kerala, India.
Microorganisms
|June 26, 2026
Summary
Postbiotics, microbial secretome derivatives, offer therapeutic benefits for diseases like cancer and autoimmune disorders. They also advance sustainable agriculture and environmental biotechnology.
Area of Science:
- Microbiology
- Biotechnology
- Immunology
Background:
- Postbiotics are microbial secretome derivatives offering functional benefits without live microbial safety concerns.
- They are emerging as biotherapeutic agents for complex diseases.
Purpose of the Study:
- To review the mechanistic insights and translational applications of postbiotics.
- To highlight their therapeutic potential in biomedical and ecological domains.
Main Methods:
- Comprehensive literature review integrating mechanistic insights and translational applications.
- Analysis of postbiotic effects on host cell signaling pathways (GPCRs, NF-κB, epigenetic pathways).
Main Results:
- Postbiotics modulate host cell signaling pathways, impacting diseases like cancer, autoimmune, and metabolic disorders.
- They exhibit localized effects such as epithelial regeneration and collagen remodeling.
- Scale-up in production opens avenues for sustainable agriculture and environmental biotechnology.
Conclusions:
- Postbiotics represent a versatile tool with potential in precision medicine and sustainable biotechnology.
- They can bridge microbiome regulation, health, and environmental challenges.
- Further research can solidify their role in addressing 21st-century health and sustainability issues.
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