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Postbiotics as Multifunctional Bioactives: Mechanistic Insights and Translational Applications in Host Physiology and

Nidhisha Babysulatha Sasidharan1, Sreetha Hely1, Subin John1

  • 1School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690525, Kerala, India.

Microorganisms
|June 26, 2026
PubMed

Insights

Postbiotics, microbial secretome derivatives, offer therapeutic benefits for diseases like cancer and autoimmune disorders. They also advance sustainable agriculture and environmental biotechnology.

Area of Science:

  • Microbiology
  • Biotechnology
  • Immunology

Background:

  • Postbiotics are microbial secretome derivatives offering functional benefits without live microbial safety concerns.
  • They are emerging as biotherapeutic agents for complex diseases.

Purpose of the Study:

  • To review the mechanistic insights and translational applications of postbiotics.
  • To highlight their therapeutic potential in biomedical and ecological domains.

Main Methods:

  • Comprehensive literature review integrating mechanistic insights and translational applications.
  • Analysis of postbiotic effects on host cell signaling pathways (GPCRs, NF-κB, epigenetic pathways).

Main Results:

  • Postbiotics modulate host cell signaling pathways, impacting diseases like cancer, autoimmune, and metabolic disorders.
  • They exhibit localized effects such as epithelial regeneration and collagen remodeling.
  • Scale-up in production opens avenues for sustainable agriculture and environmental biotechnology.

Conclusions:

  • Postbiotics represent a versatile tool with potential in precision medicine and sustainable biotechnology.
  • They can bridge microbiome regulation, health, and environmental challenges.
  • Further research can solidify their role in addressing 21st-century health and sustainability issues.
Keywords:
MAPKcancergut–skin axisimmunomodulationneurodegenerationpostbioticsshort chain fatty acid (SCFA)wound healing

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