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Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
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Related Experiment Videos

Risk-Based Pre-Admission Screening for Carbapenem-Resistant Enterobacterales (CRE): A Patient-Level Observational

Salvatore Altavilla1, Daniela Loconsole1, Nicoletta Di Pietro1

  • 1Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, 70124 Bari, Italy.

Microorganisms
|June 26, 2026
PubMed
Summary

Pre-admission screening for carbapenem-resistant Enterobacterales (CRE) identified 17.6% of at-risk patients as carriers. This risk-based approach aids in preventing hospital-acquired infections and managing patient admissions effectively.

Keywords:
CREcarbapenem-resistant Enterobacteralescarbapenemase-producing Enterobacteraleshospital epidemiologyinfection preventionpre-admission screening

Related Experiment Videos

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Multidrug-resistant organisms, especially carbapenem-resistant Enterobacterales (CRE), pose a significant global health threat.
  • Early identification of CRE colonization before hospital admission is crucial for preventing in-hospital transmission in endemic areas.

Purpose of the Study:

  • To evaluate the effectiveness of risk-based pre-admission screening for CRE in identifying colonized patients.
  • To assess the prevalence of CRE and specific carbapenemase genes in patients undergoing pre-admission screening.

Main Methods:

  • Retrospective observational study of patients evaluated for hospital admission in 2025.
  • Risk-based pre-admission screening for CRE using rectal swabs in patients with predefined risk factors.
  • Analysis of carbapenemase gene profiles, including KPC, NDM, VIM, and OXA-48.

Main Results:

  • 1084 out of 2694 patients met screening criteria; 191 (17.6%) were confirmed CRE carriers.
  • CRE prevalence was 7.1% in the overall cohort evaluated for admission.
  • KPC (53.4%) and NDM (29.8%) were the most common carbapenemase genes; co-production was observed in 7.3%.

Conclusions:

  • Risk-based pre-admission CRE screening is a pragmatic strategy in high-endemic settings for early identification of carriers.
  • This screening supports infection prevention, admission management, and infection control planning.
  • The findings highlight the importance of targeted screening to mitigate the spread of CRE within healthcare facilities.