Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Assessment of the Cardiovascular System I: Subjective Data01:23

Assessment of the Cardiovascular System I: Subjective Data

A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CGRP-Targeting Therapies in Vestibular Migraine: A Synthesis of Observational Evidence with Direction-of-Effect Analysis.

Medical sciences (Basel, Switzerland)·2026
Same author

Preliminary Psychometric Evaluation of the Romanian Version of the Hospital Anxiety and Depression Scale in Relapsing-Remitting Multiple Sclerosis.

Journal of clinical medicine·2026
Same author

New Directions in Migraine Pathophysiology: The Glymphatic System and PACAP.

Life (Basel, Switzerland)·2026
Same author

Alpha-Lipoic Acid and Benfotiamine in Diabetic Peripheral Neuropathy: A Critical Review of Mechanistic Rationale and Clinical Evidence Within a Nutritional Therapeutic Framework.

Nutrients·2026
Same author

MicroRNA profiles in multiple sclerosis: A review of the literature.

Journal of neuroimmunology·2026
Same author

Serum biomarkers insights into occult atrial fibrillation related to embolic strokes of undetermined source: a narrative review.

BMC neurology·2026

Related Experiment Video

Updated: Jun 27, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Migraine and Cardiovascular Risk: A Scoping Review of Vascular Outcomes, Risk Assessment, and Endothelial

Dan Iulian Cuciureanu1,2, Ana-Maria Nădejde2,3, Georgiana-Anca Vulpoi1,4

  • 1Neurology Department, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 16 Universității Street, 700115 Iași, Romania.

Life (Basel, Switzerland)
|June 26, 2026
PubMed
Summary

Migraine is linked to cardiovascular issues, including stroke, particularly with aura. While active migraine may not increase traditional risk scores, inflammatory markers and brain imaging show abnormalities, suggesting a need for integrated care.

Keywords:
cardiovascular riskcomorbiditiesendothelial dysfunctionischemic strokemigrainemigraine with aurascoping reviewvascular biomarkerswhite matter hyperintensities

More Related Videos

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
06:04

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Related Experiment Videos

Last Updated: Jun 27, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
06:04

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Area of Science:

  • Neurology
  • Cardiology
  • Epidemiology

Background:

  • Migraine is a global health issue affecting over a billion people.
  • It's increasingly viewed as a systemic disorder with significant cardiovascular links.
  • Understanding migraine's cardiovascular comorbidities is crucial for risk stratification and management.

Purpose of the Study:

  • To synthesize current evidence on migraine's cardiovascular comorbidities.
  • To investigate associations between migraine, stroke, endothelial function, neuroimaging, and neurocognition.
  • To map the incomplete understanding of migraine's impact on cardiovascular health.

Main Methods:

  • Systematic review following the PRISMA-ScR framework.
  • Searched PubMed/MEDLINE for recent (2015-2025) English-language human studies.
  • Included studies with large sample sizes (≥400) on cardiovascular outcomes, biomarkers, neuroimaging, or endothelial function in adult migraine patients.

Main Results:

  • Included 43 studies with over 1,500,000 participants.
  • Migraine with aura is linked to increased ischemic stroke risk, potentially via cardioembolic sources.
  • Active episodic migraine showed inverse associations with traditional cardiovascular risk scores, but elevated inflammatory markers and white matter hyperintensities were observed.

Conclusions:

  • Cardiovascular disease is a significant comorbidity of migraine.
  • Integrated, multidisciplinary management is warranted for migraine patients.
  • Future research should focus on sex-stratified designs, aura-specific risk, and cerebral endothelial function.