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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Oppositional Defiant Disorder

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Updated: Jun 27, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
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Published on: January 9, 2015

Vitamin D Deficiency and Obsessive-Compulsive Disorder Severity: A Cross-Sectional Study.

Donatella Marazziti1, Federico Mucci2, Matteo Gambini1

  • 1Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, 57, Via Roma, 56100 Pisa, Italy.

Life (Basel, Switzerland)
|June 26, 2026
PubMed
Summary

Low vitamin D levels are linked to increased obsessive-compulsive disorder (OCD) severity. This study found vitamin D deficiency common in OCD patients, correlating with higher symptom scores.

Keywords:
25-hydroxyvitamin DYale–Brown obsessive–compulsive scaleage at onsetcross-sectional studyobsessive–compulsive disordersymptom severityvitamin D

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Endocrinology

Background:

  • Obsessive-compulsive disorder (OCD) is a chronic psychiatric condition with unclear neurobiology.
  • Vitamin D may influence OCD through neuroinflammation, serotonin synthesis, and brain circuitry modulation.

Purpose of the Study:

  • To investigate the association between serum 25-hydroxyvitamin D levels and OCD symptom severity.
  • To identify vitamin D status as a potential correlate of OCD severity.

Main Methods:

  • Cross-sectional study of 306 adult OCD outpatients (173 with vitamin D measurements).
  • Assessed symptom severity using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS).
  • Analyzed associations using non-parametric tests, partial correlations, and multivariable linear regression.

Main Results:

  • Mean vitamin D was 20.0 ng/mL; 60.1% of patients were deficient.
  • Lower vitamin D levels inversely correlated with Y-BOCS total score and subscales.
  • Lower vitamin D and earlier age at onset independently predicted greater OCD severity.

Conclusions:

  • Vitamin D status is a biological correlate of OCD severity.
  • Findings support further longitudinal and interventional research on vitamin D in OCD.