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Related Concept Videos

Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Related Experiment Video

Updated: Jun 27, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Polyphenols and ADPKD: A Further Aid from Nature?

Caterina Carollo1, Alessandra Sorce1, Maria Elena Ciuppa1

  • 1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, Italy.

Life (Basel, Switzerland)
|June 26, 2026
PubMed
Summary

Plant-derived polyphenols offer a novel multi-target strategy for treating autosomal dominant polycystic kidney disease (ADPKD). Research shows these compounds can slow cyst growth by addressing inflammation, cell proliferation, and metabolic issues, though bioavailability remains a challenge.

Keywords:
ADPKDautosomal dominant polycystic kidney diseasecardiorenal syndromepolyphenolsresveratrol

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A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes
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Last Updated: Jun 27, 2026

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A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes

Published on: June 10, 2022

Area of Science:

  • Nephrology
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) presents complex therapeutic challenges due to its multifactorial nature.
  • Conventional single-target drugs for ADPKD are often limited by side effects and incomplete efficacy.
  • Plant-derived polyphenols offer a promising avenue for multi-target therapeutic strategies.

Purpose of the Study:

  • To review the potential of plant-derived polyphenols as a multi-target therapeutic strategy for ADPKD.
  • To analyze the mechanisms of action of key polyphenols including resveratrol, curcumin, naringenin, quercetin, and EGCG.
  • To identify challenges and future directions for polyphenol-based ADPKD therapies.

Main Methods:

  • Narrative review of preclinical and clinical research from 2005 to 2026.
  • Analysis of molecular mechanisms underlying polyphenol effects on ADPKD pathways.
  • Evaluation of bioavailability and formulation challenges.

Main Results:

  • Preclinical studies demonstrate that polyphenols can inhibit cystogenesis by targeting inflammation, cell proliferation, fibrosis, and cellular metabolism.
  • Specific compounds show targeted actions, e.g., naringenin interacting with polycystin-2, quercetin clearing senescent cells.
  • Clinical efficacy is hindered by poor bioavailability, as exemplified by a curcumin trial.

Conclusions:

  • Polyphenols represent a viable multi-target approach for ADPKD, addressing key disease mechanisms.
  • Improving polyphenol bioavailability through advanced formulations is critical for clinical translation.
  • Future research should focus on in vivo validation, optimized delivery systems, and combination therapies.