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Related Concept Videos

Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned under...
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques01:30

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques

Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway interventions are...
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...

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Related Experiment Video

Updated: Jun 27, 2026

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

Flow-Controlled Ventilation as a Rescue Strategy in Advanced COVID-19 ARDS: A Retrospective Observational Study.

Meltem Ceylan Delice1, Nilgun Kavrut Ozturk2

  • 1Department of Anesthesiology and Reanimation 1, SBU Van Training and Research Hospital, Van 65000, Türkiye.

Journal of Clinical Medicine
|June 26, 2026
PubMed
Summary

Flow-controlled ventilation (FCV) is technically feasible for severe COVID-19 ARDS, showing short-term gas exchange improvements. However, late initiation did not improve survival, highlighting the need for optimal timing and patient selection studies.

Keywords:
ARDSCOVID-19flow-controlled ventilationgas exchangeintensive care unitlung-protective ventilationmechanical ventilation

More Related Videos

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Related Experiment Videos

Last Updated: Jun 27, 2026

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient
07:16

An Educational Video Demonstration of How to Prone a Critically Ill Intubated Patient

Published on: November 30, 2022

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: April 7, 2021

Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Mechanical Ventilation

Background:

  • Acute respiratory distress syndrome (ARDS) in COVID-19 presents significant intensive care challenges.
  • Conventional ventilation strategies have limitations in severe respiratory failure.
  • Flow-controlled ventilation (FCV) offers precise airway pressure control but lacks extensive clinical data in ARDS.

Purpose of the Study:

  • To evaluate the feasibility and physiological effects of prolonged flow-controlled ventilation (FCV) in adult patients with moderate to severe ARDS.
  • To assess changes in gas exchange parameters during and after FCV in COVID-19 ARDS.
  • To explore the potential impact of FCV on outcomes in severe ARDS.

Main Methods:

  • Single-center retrospective observational study of seven adult patients with COVID-19-related ARDS.
  • Invasive mechanical ventilation using FCV with the Evone® ventilator and Tritube®.
  • Analysis of ventilatory settings and arterial blood gas values before, during 48 hours of FCV, and 8 hours post-FCV.

Main Results:

  • FCV initiation led to rapid PaO2 increase and improved PaO2/FiO2 ratio within 8 hours.
  • Arterial PCO2 progressively decreased, with a significant reduction within 24 hours.
  • While gas exchange improved during FCV, all patients died during ICU stay, primarily from secondary infections and pulmonary embolism.

Conclusions:

  • Prolonged FCV application is technically feasible in severe COVID-19 ARDS under ICU conditions.
  • FCV demonstrated short-term physiological benefits in gas exchange but did not confer a survival advantage.
  • Further prospective studies are essential to determine optimal timing and patient selection for FCV in ARDS.