Identifying an X-Ray Threshold for Cage Subsidence After Single-Level Minimally Invasive Transforaminal Lumbar...

Background: Cage subsidence after minimally invasive transforaminal lumbar interbody fusion raises revision risk and costs. Intraoperative computed tomography (CT) provides high-resolution, three-dimensional visualization of the endplate-cage interface and serves as a practical-though itself imperfect-reference standard for early subsidence, but it is not available at all institutions. Plain X-ray is widely available and inexpensive, but lower in resolution. The clinically relevant question is therefore not whether CT and X-ray are equivalent, but rather which X-ray protrusion depth measurement most reliably identifies CT-confirmed subsidence, and whether a positive intraoperative CT meaningfully predicts later radiographic subsidence. Objective: Using intraoperative CT as reference, we aimed to (1) determine the optimal X-ray protrusion depth threshold for CT-confirmed early subsidence; (2) test whether intraoperative CT predicts late radiographic subsidence; and (3) examine how early X-ray depth relates to intervertebral disc height (IVDH) and segmental lordosis (SL) loss. Methods: In a retrospective single-surgeon cohort (March 2015-July 2023), subsidence was defined as ≥2.0 mm endplate penetration on CT and measured on X-ray by parallax technique. Sensitivity, specificity, accuracy, and Cohen's κ were calculated. Receiver operating characteristic (ROC) analysis evaluated X-ray depth as a continuous predictor and identified the Youden-optimal cutoff. Intraoperative CT was tested against late radiographic subsidence; no-intercept linear models estimated per-millimeter IVDH and SL loss. Results: Of 100 patients, 93 had paired imaging (mean age 66.7 years; body mass index 26.8 kg/m²). Subsidence appeared on CT in 16.1% and on X-ray in 15.1%. X-ray showed 80.0% sensitivity, 97.4% specificity, 94.6% accuracy, and κ = 0.80; ROC analysis demonstrated strong discrimination (area under the curve 0.91; 95% confidence interval 0.81-1.00), Youden-optimal cutoff 1.90 mm. Intraoperative CT predicted late subsidence (n = 76) with only 45.8% sensitivity and 96.2% specificity; missed cases had penetration depths indistinguishable from non-subsiders. Each 1 mm of early X-ray depth corresponded to 0.45 mm IVDH and 0.37° SL loss. Conclusions: An X-ray protrusion depth of 2.0 mm reliably identifies CT-confirmed early subsidence, providing a preliminary diagnostic cutoff for use when CT is unavailable. Intraoperative CT is highly specific but insensitive for late subsidence; meaningful risk stratification will require additional inputs. These hypothesis-generating findings warrant prospective validation.