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Contemporary Management of Uterine Fibroids.
Olga Połukord1, Wiktoria Jędrzejak2, Patrycja Loba2
1Department of Maternal and Child Health and Minimally Invasive Gynecologic Surgery, Poznan University of Medical Sciences, 60-701 Poznan, Poland.
Journal of Clinical Medicine
|June 26, 2026
Summary
Uterine fibroid treatments are evolving towards personalized, uterus-sparing options. Minimally invasive and pharmacological therapies offer effective alternatives to surgery for many women, improving quality of life.
Area of Science:
- Gynecology
- Reproductive Medicine
- Oncology
Background:
- Uterine fibroids (leiomyomas) are common benign tumors in women of reproductive age.
- They cause significant symptoms like abnormal bleeding, pain, and infertility, impacting quality of life.
- Management is shifting towards individualized, uterus-sparing approaches.
Purpose of the Study:
- To review contemporary management strategies for uterine fibroids.
- To evaluate the efficacy and outcomes of pharmacological, minimally invasive, and surgical treatments.
- To inform personalized treatment decisions based on patient factors.
Main Methods:
- Narrative review of studies published between 2010 and 2025.
- Searched PubMed/MEDLINE, Scopus, and Web of Science databases.
- Included clinical trials, systematic reviews, and meta-analyses on uterine fibroid treatments.
Main Results:
- Minimally invasive techniques (UAE, RFA, HIFU) show high efficacy, faster recovery, and fewer complications than surgery.
- Pharmacological therapies (GnRH analogues/antagonists) reduce bleeding and fibroid volume but have side effects.
- Fertility outcomes with minimally invasive methods are variable and require careful patient selection.
Conclusions:
- Individualized uterine fibroid management is crucial, considering symptoms, fibroid characteristics, age, and reproductive goals.
- Minimally invasive and pharmacological treatments are effective alternatives to surgery for selected patients.
- Further research is needed on personalized strategies and long-term outcomes, especially fertility and recurrence.
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