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Updated: Jun 27, 2026
06:23
Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
Inflammatory Bowel Disease-Associated Spondyloarthritis
Edit Végh1, Rebeka Falcsik1, Nóra Bodnár1
1Department of Rheumatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Journal of Clinical Medicine
|June 26, 2026
Summary
Inflammatory bowel disease-associated spondyloarthritis (IBD-SpA) involves complex gut-joint pathways. Treatment requires careful consideration of drug suitability for both conditions, potentially including diet and microbiome-focused therapies.
Area of Science:
- Rheumatology
- Gastroenterology
- Immunology
Background:
- Spondyloarthritis associated with inflammatory bowel diseases (IBD-SpA), or enteropathic arthritis, is a distinct spondyloarthritis subtype.
- Recent research has significantly advanced understanding of IBD-SpA pathogenesis and treatment.
Purpose of the Study:
- To review the current knowledge on IBD-SpA, focusing on pathogenesis, genetics, environmental factors, and immunopathology.
- To discuss clinical manifestations, diagnostics, and therapeutic strategies for IBD-SpA.
Main Methods:
- Narrative review of recent literature on IBD-SpA.
- Analysis of pathogenetic pathways, genetic factors, microbiome influence, and immune responses.
- Evaluation of current and future treatment options.
Main Results:
- IBD-SpA pathogenesis involves intricate gut-joint axis interactions, influenced by genetics, environment, and the microbiome.
- Shared and distinct immunopathological processes are observed in IBD and SpA.
- Pharmacotherapy for SpA and IBD requires careful selection, as some arthritis treatments may exacerbate IBD.
Conclusions:
- IBD-SpA management necessitates a nuanced approach, considering the interplay between gut and joint inflammation.
- Non-pharmacological interventions, such as dietary changes and short-chain fatty acids (SCFAs), show promise.
- Future treatments may involve personalized and rational therapeutic strategies targeting specific pathogenetic pathways.
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