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Association of Triglyceride-Glucose Index with Negative Clinical Outcomes in Geriatric Patients with Chronic Heart

Li Tian1,2, Xuan Qiu3, Qiqi Cheng4

  • 1School of Nursing, Wuhan University, Wuhan 430072, China.

Journal of Clinical Medicine
|June 26, 2026
PubMed

Insights

The triglyceride-glucose (TyG) index, a marker for insulin resistance, independently predicts heart failure rehospitalization in older adults. While not significantly linked to mortality after adjustment, it aids in risk stratification and nursing care for chronic heart failure patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Geriatrics

Background:

  • Insulin resistance is a key factor in chronic heart failure (CHF) pathophysiology.
  • The triglyceride-glucose (TyG) index is a validated surrogate marker for insulin resistance.
  • Predictive markers for adverse outcomes in elderly CHF patients are crucial for effective management.

Purpose of the Study:

  • To assess the prognostic value of the TyG index for heart failure rehospitalization and all-cause mortality in older adults with CHF.
  • To evaluate the clinical utility of the TyG index in risk stratification and guiding nursing care for this population.

Main Methods:

  • A single-center retrospective cohort study included 786 elderly patients (≥65 years) with CHF.
  • Patients were categorized into low vs. high TyG index groups based on the median.
  • Statistical analyses included Kaplan-Meier curves, restricted cubic spline regression, and multivariable Cox models.

Main Results:

  • The median TyG index was 8.35.
  • A higher TyG index was associated with increased risks of heart failure rehospitalization and all-cause mortality in unadjusted analyses.
  • After multivariable adjustment, the TyG index remained an independent predictor of heart failure rehospitalization (HR = 1.63) but not all-cause mortality.

Conclusions:

  • The TyG index independently predicts heart failure rehospitalization in elderly patients with chronic heart failure, with a nonlinear dose-response relationship.
  • The independent association with all-cause mortality was attenuated after full adjustment.
  • The TyG index shows potential for aiding risk stratification and personalized nursing interventions in this patient group.

Keywords:
Kaplan–Meier survival curveTyG indexall-cause mortalitychronic heart failureheart failure rehospitalization

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