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Updated: Jun 27, 2026
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In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model
Published on: November 17, 2018
ONX-0914 Alleviates Impaired Diabetic Wound Healing by Restoring Redox Homeostasis and Modulating Pro-Inflammatory
Betül Çıkı1,2, Damla Kayalı3, Hafize Uzun2
1Department of Medical Biochemistry, Faculty of Medicine, Marmara University, Istanbul 34854, Türkiye.
Medicina (Kaunas, Lithuania)
|June 26, 2026
Summary
ONX-0914 treatment significantly accelerates diabetic wound healing in rats. This drug restores antioxidant defenses, reduces inflammation, and improves tissue repair, offering a promising therapeutic strategy for diabetes-related wound complications.
Area of Science:
- Biomedical Science
- Pharmacology
- Wound Healing Research
Background:
- Diabetes mellitus (DM) impairs wound healing via oxidative stress, inflammation, and proteasome dysfunction.
- Diabetic ulcers pose a significant clinical challenge due to delayed tissue repair.
Purpose of the Study:
- Investigate the immunoproteasome system's role in diabetic wound healing.
- Evaluate the efficacy of ONX-0914, an immunoproteasome inhibitor, in improving diabetic wound repair.
Main Methods:
- Streptozotocin (STZ)-induced diabetes in rats with control, diabetic, and ONX-0914 treated groups.
- Assessed wound closure, histopathology, oxidative stress markers (MDA, SOD, CAT, GSH-Px), proteasome activity, and inflammatory cytokines (IL-1β, TNF-α, IL-6).
Main Results:
- STZ-induced diabetes delayed wound healing, increased oxidative stress, and elevated inflammation.
- ONX-0914 treatment accelerated wound closure, improved histological parameters, reduced oxidative damage, and suppressed inflammatory markers.
Conclusions:
- ONX-0914 significantly enhances diabetic wound healing.
- Immunoproteasome inhibition by ONX-0914 restores antioxidant capacity and reduces inflammation, indicating therapeutic potential for diabetic wound complications.
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