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Updated: Jun 27, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
The Oral-Gut Microbiome Connection in Patients with Periodontitis: A Systematic Review
Damaris Anton1, Mihaela Băciuț2, Oana Almășan1
1Department of Prosthetic Dentistry and Dental Materials, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Medicina (Kaunas, Lithuania)
|June 26, 2026
Summary
Periodontal disease, linked to oral-gut microbial changes, may increase systemic inflammation risks. Periodontal treatment shows potential for improving gut health and overall well-being.
Area of Science:
- Microbiome research
- Periodontology
- Systemic health
Background:
- Periodontal disease is associated with chronic inflammation.
- The oral-gut axis is increasingly recognized for its role in systemic health.
- Understanding the link between oral health and gut microbiome is crucial.
Purpose of the Study:
- To review current literature on the oral-gut connection in periodontal disease.
- To evaluate the impact of periodontal disease on the gut microbiome and systemic inflammation.
- To assess the potential health benefits of periodontal treatment on the gut microbiome.
Main Methods:
- Systematic literature search across three databases (October 1-20, 2025).
- Screening of 578 articles based on inclusion/exclusion criteria.
- Methodological quality assessed using Newcastle-Ottawa scale and Risk of Bias 2 Tool.
Main Results:
- Eleven studies were included, showing similarities between oral and gut microbiomes in periodontitis patients.
- Gut microbial shifts are linked to systemic inflammation, metabolic dysfunction, and compromised gut barrier.
- Non-surgical periodontal therapy correlated with gut microbiota improvements.
Conclusions:
- Evidence supports an association between periodontitis, oral-gut dysbiosis, and systemic inflammation.
- Observational nature of studies limits causal inference.
- Gut microbiome modulation is a potential future research area, but clinical applicability is uncertain.
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