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Related Experiment Video

Updated: Jun 27, 2026

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
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Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish

Published on: July 16, 2012

Biomarker Research in NSAID Hypersensitivity: A Scoping Review and Evidence Map.

Yu Kyoung Hwang1

  • 1Division of Allergy, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju-si 28644, Republic of Korea.

Pharmaceuticals (Basel, Switzerland)
|June 26, 2026
PubMed
Summary

Biomarker research for nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity is concentrated in a few phenotypes, primarily NSAID-exacerbated respiratory disease. Most studies remain in early discovery stages with limited validation.

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Area of Science:

  • Pharmacogenomics
  • Clinical Immunology
  • Biomarker Discovery

Background:

  • Nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity presents diverse clinical phenotypes impacting diagnosis and treatment.
  • Current biomarker research is fragmented, hindering comprehensive interpretation and clinical application.
  • A systematic mapping of existing literature is needed to understand research distribution and identify gaps.

Purpose of the Study:

  • To map NSAID hypersensitivity biomarker studies across harmonized phenotype categories.
  • To analyze the distribution of biomarker classes and their intended clinical uses.
  • To assess the translational validation stages of NSAID hypersensitivity biomarker research.

Main Methods:

  • A scoping review methodology was employed with systematic literature searches in PubMed and Embase.
Keywords:
NERDNSAID hypersensitivityaspirin-exacerbated respiratory diseasebiomarkerevidence mappingscoping reviewtranslational validation

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Last Updated: Jun 27, 2026

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  • Records published between January 2005 and March 2026 were screened and deduplicated.
  • Eligible studies were classified using frameworks for phenotype, biomarker, intended use, and validation stage.

    • Main Results:

    • The review included 218 deduplicated records, heavily focused on NSAID-exacerbated respiratory disease/aspirin-exacerbated respiratory disease (NERD/AERD).
    • Genetic biomarkers were the most common class, frequently associated with NERD/AERD.
    • The majority of studies were in Stage 0 exploratory discovery, focusing on phenotype/endotype stratification, with limited later-stage validation.

    Conclusions:

    • The current body of NSAID hypersensitivity biomarker literature is concentrated in a narrow phenotypic range.
    • Research predominantly remains in the exploratory phase, lacking robust validation for clinical translation.
    • Future research should emphasize phenotype harmonization, diagnostic anchoring, standardized biospecimens, and independent validation.