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Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.
Ivan Maria Smoday1, Vlasta Vukovic1, Katarina Oroz1
1Department of Pharmacology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Pharmaceuticals (Basel, Switzerland)
|June 26, 2026
Summary
Stable gastric pentadecapeptide BPC 157 therapy counteracted severe vascular and multiorgan failure following unilateral adrenalectomy in rats. This peptide therapy demonstrated significant organ protection and reversed thrombosis, highlighting its potential therapeutic benefits for vascular disturbances.
Area of Science:
- Gastroenterology and Hepatology
- Vascular Surgery
- Endocrinology
Background:
- Unilateral adrenalectomy in rats induces significant vascular and multiorgan failure.
- This condition is associated with occlusion/occlusion-like syndrome and oxidative stress.
- Stable gastric pentadecapeptide BPC 157 has shown potential cytoprotective and vascular recovery effects.
Purpose of the Study:
- To investigate the therapeutic effects of BPC 157 on rats subjected to unilateral adrenalectomy.
- To evaluate the impact of BPC 157 on vascular integrity, organ damage, and occlusion/occlusion-like syndrome.
- To elucidate the mechanistic pathways involved in BPC 157's protective effects.
Main Methods:
- Rats underwent unilateral adrenalectomy at various time points.
- BPC 157 therapy was administered orally at specific dosages (10 µg/kg, 10 ng/kg).
- Gross morphology, vascular alterations, oxidative stress markers, and molecular changes were assessed.
Main Results:
- BPC 157 counteracted lesions in multiple organs (adrenal, brain, heart, liver, kidney, GI tract), hemorrhage, and thrombosis.
- Arrhythmias, hypertension (intracranial, portal, caval), and hypotension were attenuated.
- The therapy promoted collateral pathway activation, improved blood flow, and reversed Virchow's triad conditions.
- BPC 157 normalized adrenal lesions, modulated cortisol levels, and promoted compensatory weight gain.
- Mechanistically, BPC 157 modulated the NO-system, balanced oxidative stress (reduced malondialdehyde), and upregulated NOS1-3 and VEGF-A expression.
Conclusions:
- BPC 157 therapy effectively counteracted severe systemic complications arising from unilateral adrenalectomy in rats.
- The peptide demonstrated significant organ protection, vascular repair, and reversal of thrombotic conditions.
- BPC 157's mechanism involves NO-system modulation and oxidative stress balance, warranting further investigation for clinical applicability.
Keywords:
BPC 157peripheral and central occlusion/occlusion-like syndromeunilateral adrenalectomyvascular recovery effect
