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Composite-Structured Anti-Resonant Fiber with High Temperature Sensitivity for Cancer Cell Detection.

Ruifan Wu1, Qiming Wang1, Yongqi Gai1

  • 1School of Information Science and Engineering, Shenyang University of Technology, No. 111, Shenliao West Road, Economic & Technological Development Zone, Shenyang 110870, China.

Sensors (Basel, Switzerland)
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

A novel egg-shaped fiber sensor utilizing surface plasmon resonance (SPR) offers high sensitivity for detecting cancer cells and monitoring temperature. This label-free biosensor shows significant potential for medical diagnostics and environmental applications.

Keywords:
SPR effectanti-resonant fibercancer cell detectiontemperature sensing

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Area of Science:

  • Optoelectronics
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Surface Plasmon Resonance (SPR) sensors are crucial for label-free detection.
  • Existing fiber optic sensors face limitations in sensitivity and specificity for complex biological samples.
  • Novel sensor designs are needed for enhanced performance in cancer cell detection.

Purpose of the Study:

  • To propose and optimize a novel anti-resonant fiber sensing structure with a composite "egg-shaped" configuration.
  • To investigate the sensor's performance for both temperature sensing and cancer cell detection.
  • To evaluate the sensor's potential for label-free, high-sensitivity applications in medical diagnostics and environmental monitoring.

Main Methods:

  • Designed a composite anti-resonant fiber structure (semicircle and semi-ellipse) coated with gold film.
  • Utilized simulation experiments with temperature sensitivity as the optimization criterion.
  • Applied the optimized sensor to simulated detection and analysis of six types of cancer cells.

Main Results:

  • Achieved a maximum temperature sensitivity (TS) of 3.86 nm/°C.
  • Demonstrated excellent performance for cancer cell detection with maximum wavelength sensitivity (WS) of 12,142.86 nm/RIU.
  • Reported optimal resolution (R) of 8.24 × 10-6, FOM of 3035.72 RIU-1, SNR of 65.50, and LOD of 0.94 nm.

Conclusions:

  • The proposed "egg-shaped" SPR fiber sensor exhibits high sensitivity and excellent performance for temperature and cancer cell detection.
  • The label-free sensing mechanism offers broad application prospects in environmental monitoring and medical prevention and treatment.
  • This novel sensor design provides a valuable reference for developing advanced optical fiber sensors.